Exploratory analysis of the platelet-to-lymphocyte ratio prognostic value in the adjuvant renal cell cancer setting

被引：3

作者：

Patel, Anup

Ravaud, Alain ^{[1
]}

Motzer, Robert J. ^{[2
]}

Pantuck, Allan J. ^{[3
]}

Staehler, Michael ^{[4
]}

Escudier, Bernard ^{[5
]}

Martini, Jean-Francois ^{[6
]}

Lechuga, Mariajose ^{[7
]}

Lin, Xun ^{[6
]}

George, Daniel J. ^{[8
]}

机构：

[1] Bordeaux Univ Hosp, F-33000 Bordeaux, France

[2] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[3] UCLA, David Geffen Sch Med, Los Angeles, CA 90094 USA

[4] Univ Hosp Munich, D-80336 Munich, Germany

[5] Inst Gustave Roussy, F-94800 Villejuif, France

[6] Pfizer Inc, La Jolla, CA 92121 USA

[7] Pfizer SrL, Via Anna Maria Mozzoni 12, I-20152 Milan, Italy

[8] Duke Canc Inst, Durham, NC 27710 USA

来源：

FUTURE ONCOLOGY | 2020年 / 17卷 / 04期

关键词：

adjuvant; lymphocyte; platelet; prognostic; renal cell carcinoma; sunitinib; HIGH-RISK; CARCINOMA; SUNITINIB; PLACEBO;

D O I：

10.2217/fon-2020-0652

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim:To examine the prognostic value of the platelet-to-lymphocyte ratio (PLR) in the adjuvant renal cell carcinoma setting.Materials & methods:Patients received adjuvant sunitinib (50 mg/day; 4 weeks on/2 weeks off) or placebo. The primary end point was disease-free survival (DFS).Results:In 609 patients, DFS was similar for baseline PLR <140 versus >= 140 overall (median: 6.4 vs 5.9 years; hazard ratio: 0.9; 95% CI: 0.7-1.2). A >= 25% decrease in PLR at week 4 overall was associated with longer DFS versus no change (hazard ratio: 0.8; 95% CI: 0.6-1.0).Conclusion:Baseline PLR was not prognostic for DFS with adjuvant sunitinib treatment in patients with renal cell carcinoma. Clinical Trials Registration:()

引用

页码：403 / 409

页数：7

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