SMALL-MOLECULE INHIBITORS bULKing up mTOR inhibition

被引：1
|
作者：
Goodwin, Jonathan M. [1 ]
Murphy, Leon O. [1 ]
机构：
[1] Novartis Inst BioMed Res, Cambridge, MA 02139 USA
来源：
NATURE CHEMICAL BIOLOGY | 2015年 / 11卷 / 10期
关键词：
DIRECT PHOSPHORYLATION; IN-VIVO; AUTOPHAGY; KINASE; TARGET; VPS34; ULK1;
D O I：
10.1038/nchembio.1909
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new small-molecule inhibitor of the autophagy-initiating kinase ULK1 serves to block a critical survival mechanism activated upon inhibition of mTORC1, potentially enhancing treatment efficacy for mTOR inhibitors currently in clinical trials for cancer treatment.
引用
收藏
页码：758 / 760
页数：4
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