Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies

被引:634
作者
Palmer, Suetonia [1 ]
Vecchio, Mariacristina [2 ]
Craig, Jonathan C. [3 ]
Tonelli, Marcello [4 ]
Johnson, David W. [5 ]
Nicolucci, Antonio [2 ]
Pellegrini, Fabio [2 ,6 ]
Saglimbene, Valeria [2 ]
Logroscino, Giancarlo [7 ]
Fishbane, Steven [8 ]
Strippoli, Giovanni F. M. [2 ,3 ,9 ,10 ]
机构
[1] Univ Otago, Dept Med, Christchurch, New Zealand
[2] Consorzio Mario Negri Sud, Dept Clin Pharmacol & Epidemiol, I-66030 Santa Maria Imbaro, Italy
[3] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia
[4] Univ Alberta, Dept Med, Edmonton, AB, Canada
[5] Univ Queensland, Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia
[6] IRCCS, Casa Sollievo Sofferenza Hosp, Foggia, Italy
[7] Univ Bari, Dept Neurol & Psychiat, Bari, Italy
[8] Hofstra North Shore LIJ Sch Med, Dept Med, Great Neck, NY USA
[9] Diaverum Sci Off, Lund, Sweden
[10] Univ Bari, Dept Emergency & Organ Transplantat, Bari, Italy
关键词
depression; dialysis; quality of life; QUALITY-OF-LIFE; STAGE RENAL-DISEASE; JAPAN DIALYSIS OUTCOMES; HEMODIALYSIS-PATIENTS; MAJOR DEPRESSION; PSYCHIATRIC-DISORDERS; FOLLOW-UP; NUTRITIONAL-STATUS; SYMPTOMS PREDICT; HEALTH;
D O I
10.1038/ki.2013.77
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Prevalence estimates of depression in chronic kidney disease (CKD) vary widely in existing studies. We conducted a systematic review and meta-analysis of observational studies to summarize the point prevalence of depressive symptoms in adults with CKD. We searched MEDLINE and Embase (through January 2012). Random-effects meta-analysis was used to estimate the prevalence of depressive symptoms. We also limited the analyses to studies using clinical interview and prespecified criteria for diagnosis. We included 249 populations (55,982 participants). Estimated prevalence of depression varied by stage of CKD and the tools used for diagnosis. Prevalence of interview-based depression in CKD stage 5D was 22.8% (confidence interval (CI), 18.6-27.6), but estimates were somewhat less precise for CKD stages 1-5 (21.4% (CI, 11.1-37.2)) and for kidney transplant recipients (25.7% (12.8-44.9)). Using self-or clinician-administered rating scales, the prevalence of depressive symptoms for CKD stage 5D was higher (39.3% (CI, 36.8-42.0)) relative to CKD stages 1-5 (26.5% (CI, 18.5-36.5)) and transplant recipients (26.6% (CI, 20.9-33.1)) and suggested that self-report scales may overestimate the presence of depression, particularly in the dialysis setting. Thus, interview-defined depression affects approximately one-quarter of adults with CKD. Given the potential prevalence of depression in the setting of CKD, randomized trials to evaluate effects of interventions for depression on patient-centered outcomes are needed.
引用
收藏
页码:179 / 191
页数:13
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