The Beauty and Complexity of Blood Vessel Patterning

被引：3

作者：

Bautch, Victoria L. L. ^{[1
,2
,3
]}

Mukouyama, Yoh-suke ^{[4
]}

机构：

[1] Univ North Carolina Chapel Hill, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, McAllister Heart Inst, Chapel Hill, NC 27599 USA

[3] Univ North Carolina Chapel Hill, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[4] Natl Heart Lung & Blood Inst, NIH, Cell & Dev Biol Ctr, Lab Stem Cell & Neurovasc Biol, Bethesda, MD 20892 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2022年 / 12卷 / 11期

关键词：

HEREDITARY HEMORRHAGIC TELANGIECTASIA; BRAIN ARTERIOVENOUS-MALFORMATIONS; ENDOTHELIAL-GROWTH-FACTOR; CHEMOKINE RECEPTOR CXCR4; CORONARY-ARTERY; VE-CADHERIN; NEUROVASCULAR DEVELOPMENT; SPROUTING ANGIOGENESIS; CELL-MIGRATION; MOUSE MODEL;

D O I：

10.1101/cshperspect.a041167

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This review highlights new concepts in vascular patterning in the last 10 years, with emphasis on its beauty and complexity. Endothelial cell signaling pathways that respond to molecular or mechanical signals are described, and examples of vascular patterning that use these pathways in brain, skin, heart, and kidney are highlighted. The pathological consequences of patterning loss are discussed in the context of arteriovenous malformations (AVMs), and prospects for the next 10 years presented.

引用

页数：23

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