Small bowel adenocarcinoma with high levels of microsatellite instability in Crohn's disease

被引：9

作者：

Chan, RCF

Katelaris, PH

Stewart, P

Lin, BPC ^{[1
]}

机构：

[1] Concord Hosp, Dept Anat Pathol, Concord, NSW 2139, Australia

[2] Concord Hosp, Dept Gastroenterol, Concord, NSW 2139, Australia

[3] Concord Hosp, Dept Colorectal Surg, Concord, NSW 2139, Australia

[4] Univ Sydney, Sydney, NSW 2006, Australia

来源：

HUMAN PATHOLOGY | 2006年 / 37卷 / 05期

关键词：

adenocarcinoma; microsatellite-high; Crohn's; small bowel;

D O I：

10.1016/j.humpath.2005.12.013

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Microsatellite instability (MSI) is a hallmark of carcinomas occurring in the setting of hereditary nonpolyposis colorectal cancer, but can also be found in sporadic and colitis-associated tumors. The incidence of MSI in Crohn's disease is unknown and has Usually been reported in the colon. We report the case of a 26-year-old man, diagnosed 4 years earlier with Crohn's disease, who developed an associated small bowel adenocarcinoma. The tumor was found to have high levels of MSI by immunohistochemical staining and by MSI testing. No mutations were identified by genetic testing, and high levels of MSI are most probably due to hypermethylation. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：631 / 634

页数：4

共 15 条

[1] Synchronous ileal and colonic adenocarcinomas associated with Crohn's disease: report of a case with a focus on genetic alterations and carcinogenesis [J].