RhIII/CuII-Cocatalyzed Synthesis of 1H-Indazoles through C-H Amidation and N-N Bond Formation

被引：314
作者：
Yu, Da-Gang [1 ]
Suri, Mamta [1 ]
Glorius, Frank [1 ]
机构：
[1] Univ Munster, Organ Chem Inst, Int NRW Grad Sch Chem, D-48149 Munster, Germany
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 24期
基金：
欧洲研究理事会;
关键词：
D O I：
10.1021/ja4033555
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Substituted 1H-indazoles can be formed from readily available arylimidates and organo azides by Rh-III-catalyzed C-H activation/C-N bond formation and Cu-catalyzed N-N bond formation. For the first time the N-H-imidates are demonstrated to be good directing groups in C-H activation, also capable of undergoing intramolecular N-N bond formation. The process is scalable and green, with O-2 as the terminal oxidant and N-2 and H2O formed as byproducts. Moreover, the products could be transformed to diverse important derivatives.
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收藏
页码：8802 / 8805
页数：4
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