Gastroesophageal reflux in the neonate

Gastroesophageal reflux is a common problem in the neonate, with varied clinical presentation. Much of the information on gastroesophageal reflux in neonates is largely from older infants and children. The symptoms resulting from gastroesophageal reflux disease in neonates are not very clear with regards to cause and association. This article summarizes the current literature regarding physiologic and pathologic neonatal gastroesophageal reflux to a larger extent, and discusses clinical presentation and available treatment options of a disease whose pathophysiology is not very clear in neonates.