Prolyl endopeptidase inhibitors derived from actinomycetes

被引：10

作者：

Kimura, K ^{[1
]}

Kanou, F ^{[1
]}

Yamashita, Y ^{[1
]}

Yoshimoto, T ^{[1
]}

Yoshihama, M ^{[1
]}

机构：

[1] NAGASAKI UNIV, SCH PHARMACEUT SCI, NAGASAKI 852, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 10期

关键词：

prolyl endopeptidase; inhibitor; actinomycetes; natural product;

D O I：

10.1271/bbb.61.1754

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four prolyl endopeptidase inhibitors isolated from actinomycetes, named propeptin, SNA-8073-B, staurosporine, and enduracidin were classified into 3 groups on the basis of their inhibition potency against prolyl endopeptidase from a bacterium (Flavobacterium) and a mammal (human placenta). Staurosporine inhibited the enzyme from Flavobacterium more strongly than that from human placenta. Enduracidin inhibited the enzyme from human placenta more strongly than that from Flavobacterium. Propeptin and SNA-8073-B, both new compounds, inhibited the enzymes from both origins to the same extent.

引用

页码：1754 / 1756

页数：3

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