Exercise and inflammation

被引：136

作者：

Metsios, George S. ^{[1
,2
,3
]}

Moe, Rikke H. ^{[4
]}

Kitas, George D. ^{[2
,5
]}

机构：

[1] Univ Wolverhampton, Fac Educ Hlth & Wellbeing, Wolverhampton, W Midlands, England

[2] Dudley Grp NHS Fdn Trust, Russells Hall Hosp, Dept Rheumatol, Dudley, England

[3] Univ Thessaly, Sch Phys Educ & Sport Sci, Volos, Greece

[4] Diakonhjemmet Hosp, Dept Rheumatol, Natl Resource Ctr Rehabil Rheumatol, Oslo, Norway

[5] Univ Birmingham, Sch Sport Exercise & Rehabil Sci, Birmingham, W Midlands, England

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2020年 / 34卷 / 02期

关键词：

Exercise; Physical activity; Rheumatoid arthritis; Non-communicable disease; Autoimmune disease; Cardiovascular disease; Inflammation; Rehabilitation; C-REACTIVE PROTEIN; SKELETAL-MUSCLE; RHEUMATOID-ARTHRITIS; CARDIOVASCULAR-DISEASE; ENERGY-EXPENDITURE; PHYSICAL-EXERCISE; MESSENGER-RNA; INTERLEUKIN-6; CACHEXIA; METAANALYSIS;

D O I：

10.1016/j.berh.2020.101504

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Based on current knowledge deriving from studies in animals and humans (the general population and patients with non-communicable diseases), there is biological plausibility that exercise may have anti-inflammatory effects. This may be particularly important for patients with chronic inflammatory rheumatic and musculoskeletal diseases (RMDs). The present review discusses the current state-of-the-art on exercise and inflammation, explores how exercise can moderate inflammation-dependent RMD outcomes and the most prevalent systemic manifestations and addresses the relationship between the dosage (particularly the intensity) of exercise and inflammation. We conclude that present data support potential beneficial effects of exercise on inflammation, however, the evidence specifically in RMDs is limited and inconclusive. More targeted research is required to elucidate the effects of exercise on inflammation in the context of RMDs. (C) 2020 Published by Elsevier Ltd.

引用

页数：12

共 78 条

[1] Inflammation in osteoarthritis [J].

Goldring, Mary B. ;

Otero, Miguel .

CURRENT OPINION IN RHEUMATOLOGY, 2011, 23 (05) :471-478

[2] EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update [J].

Agca, R. ;

Heslinga, S. C. ;

Rollefstad, S. ;

Heslinga, M. ;

McInnes, B. ;

Peters, M. J. L. ;

Kvien, T. K. ;

Dougados, M. ;

Radner, H. ;

Atzeni, F. ;

Primdahl, J. ;

Sodergren, A. ;

Jonsson, S. Wallberg ;

van Rompay, J. ;

Zabalan, C. ;

Pedersen, T. R. ;

Jacobsson, L. ;

de Vlam, K. ;

Gonzalez-Gay, M. A. ;

Semb, A. G. ;

Kitas, G. D. ;

Smulders, Y. M. ;

Szekanecz, Z. ;

Sattar, N. ;

Symmons, D. P. M. ;

Nurmohamed, M. T. .

ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (01) :17-28

[3] IL-6 AND NF-IL6 IN ACUTE-PHASE RESPONSE AND VIRAL-INFECTION [J].

AKIRA, S ;

KISHIMOTO, T .

IMMUNOLOGICAL REVIEWS, 1992, 127 :25-50

[4] The role of muscle strengthening in exercise therapy for knee osteoarthritis: A systematic review and meta-regression analysis of randomized trials [J].

Bartholdy, Cecilie ;

Juhl, Carsten ;

Christensen, Robin ;

Lund, Hans ;

Zhang, Weiya ;

Henriksen, Marius .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2017, 47 (01) :9-21

[5] Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation [J].

Benatti, Fabiana B. ;

Pedersen, Bente K. .

NATURE REVIEWS RHEUMATOLOGY, 2015, 11 (02) :86-97

[6] Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage [J].

Bruunsgaard, H ;

Galbo, H ;

HalkjaerKristensen, J ;

Johansen, TL ;

MacLean, DA ;

Pedersen, BK .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 499 (03) :833-841

[7] The impact of physical activity on serum levels of inflammatory markers in rheumatoid arthritis: a systematic literature review [J].

Burghardt, Rolf-Dieter ;

Kazim, Murteza Ali ;

Ruether, Wolfgang ;

Niemeier, Andreas ;

Strahl, Andre .

RHEUMATOLOGY INTERNATIONAL, 2019, 39 (05) :793-804

[8] Fibrinogen as a key regulator of inflammation in disease [J].

Davalos, Dimitrios ;

Akassoglou, Katerina .

SEMINARS IN IMMUNOPATHOLOGY, 2012, 34 (01) :43-62

[9] PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle [J].

Dinulovic, Ivana ;

Furrer, Regula ;

Di Fulvio, Sabrina ;

Ferry, Arnaud ;

Beer, Markus ;

Handschin, Christoph .

SKELETAL MUSCLE, 2016, 6

[10] The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo [J].

Eisele, Petra Sabine ;

Furrer, Regula ;

Beer, Markus ;

Handschin, Christoph .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 464 (03) :692-697

← 1 2 3 4 5 6 7 8 →