Detecting Breath Ammonia for Non-invasive Diagnostic based on Low-Cost Organic Diode with Vertical Nanojunctions

被引：0

作者：

Dai, Ming-Zhi ^{[1
]}

Lin, Yi-Lo ^{[2
,3
]}

Lin, Hong-Cheng ^{[4
]}

Zan, Hsiao-Wen ^{[4
]}

Chang, Kai-Ting ^{[3
]}

Meng, Hsin-Fei ^{[1
]}

Liao, Jiunn-Wang ^{[2
]}

Tsai, May-Jywan ^{[3
]}

Cheng, Henrich ^{[3
,5
]}

机构：

[1] Natl Chiao Tung Univ, Inst Phys, Hsinchu, Taiwan

[2] Natl Chung Hsing Univ, Coll Vet Med, Grad Inst Vet Pathobiol, Taichung, Taiwan

[3] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Neural Regenerat Lab, Taipei, Taiwan

[4] Natl Chiao Tung Univ, Dept Photon, Hsinchu, Taiwan

[5] Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei, Taiwan

来源：

2012 IEEE SENSORS PROCEEDINGS | 2012年

关键词：

HEPATIC-ENCEPHALOPATHY; LIVER-CIRRHOSIS; FAILURE; RATS;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We propose a novel solid-state electrical ammonia sensor based on a vertical organic diode with high-density nanopores in the top electrode. The proposed ammonia sensor has a detection limit of 20 ppb, a real-time response, sufficient selectivity, simple structure, high reproducibility, and a low production cost. In addition, we used the proposed sensor to detect the nasal breath of rats directly. After controlling the relative humidity and filtering out the CO2, we successfully obtained repeated real-time, reliable responses. This is the first demonstration of a solid-state sensor having reliable responses to the breath ammonia of an animal. The sensing response between normal and acute groups is significantly different (p < 0.05). These results demonstrated that the proposed ammonia sensor can detect liver that undergoes moderate hepatopathy.

引用

页码：908 / 911

页数：4