Bio- and Medicinally Compatible α-Amino-Acid Modification via Merging Photoredox and N-Heterocyclic Carbene Catalysis

被引：28

作者：

Du, Ding ^{[1
]}

Zhang, Kuili ^{[1
]}

Ma, Rui ^{[1
]}

Chen, Lei ^{[1
]}

Gao, Jian ^{[1
]}

Lu, Tao ^{[1
]}

Shi, Zhihao ^{[1
]}

Feng, Jie ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Organ Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 16期

基金：

中国国家自然科学基金;

关键词：

AZA-BENZOIN REACTIONS; KETONES; ALKYLATION; OXIDATION; ALDEHYDES; ENALS;

D O I：

10.1021/acs.orglett.0c02202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An N-heterocyclic carbene and photoredox cocatalyzed alpha-amino-acid decarboxylative carbonylation reaction is presented. This method displays good scope generality, providing a direct pathway to access various downstream alpha-amino ketones under bio- and medicinally compatible conditions. Moreover, this strategy is appealing to chemical biology because it has great potential for the chemical modification of peptides or the late-stage synthesis of keto-peptides.

引用

页码：6370 / 6375

页数：6

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