Diastereoselective three-component Mannich reaction catalyzed by silica-supported ferric hydrogensulfate

被引：20

作者：

Eshghi, Hossein ^{[1
]}

Rahimizadeh, Mohammad ^{[1
]}

Hosseini, Mohsen ^{[1
]}

Javadian-Saraf, Aida ^{[1
]}

机构：

[1] Ferdowsi Univ Mashhad, Sch Sci, Dept Chem, Mashhad 917751436, Iran

来源：

MONATSHEFTE FUR CHEMIE | 2013年 / 144卷 / 02期

关键词：

Three-component; Diastereoselective anti-Mannich reaction; Silica-supported ferric hydrogensulfate; Iron heterogeneous catalysis; 3 COMPONENT SYNTHESIS; BETA-AMINO KETONES; ONE-POT; ANTI-MANNICH; ASYMMETRIC-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; AROMATIC-ALDEHYDES; IONIC LIQUID; ACID; EFFICIENT;

D O I：

10.1007/s00706-012-0800-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly anti-diastereoselective three-component Mannich reaction of aromatic amines and aromatic aldehydes with cyclohexanone in the presence of silica-supported ferric hydrogensulfate has been developed. The best selectivity was obtained where there were electron-donating groups on both aldehyde and amine. Selectivity decreases when electron-withdrawing groups are present on the aldehyde; in these cases selectivity is improved if an electron-donating group is present on the amine.

引用

页码：197 / 203

页数：7

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