Caloric restriction in nonmammalian models

The well-known effects of caloric restriction (CR) upon life span have been studied in a number of nonmammalian species, from yeast to fish. Early work focused on determining whether CR could prolong life span, which it does in most organisms thus far examined. More recently, studies done with invertebrates models, including yeast, Caenorhabditis elegans, and Drosophila, have suggested potential mechanistic commonalities with CR. In this review, a survey of data collected from the application of CR to a number of nonmammalian models is presented, as well as the potential molecular overlap arising from work done with invertebrates.