Catalytic enantioselective 1,3-dipolar cycloaddition reactions of azomethine ylides and alkenes by using phosphoramidite-silver(I) complexes

被引：113
|
作者：
Najera, Carmen [1 ]
Retamosa, M. de Gracia [1 ]
Sansano, Jose M. [1 ]
机构：
[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, Alicante 03080, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 32期
关键词：
azomethine ylides; chirality; cycloaddition; phosphoramidites; silver;
D O I：
10.1002/anie.200801690
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Presented) Silver catalysts: A novel chiral phosphoramidite -silver perchlorate complex has been used for the synthesis of highly substituted pyrolidine rings. This method is valuable for the synthesis of biologically active α-substituted prolines by using hindered dipoles generated from α-substituted α amino acids (see scheme; DABCO=1,4-diazabicyclo[2.2.2]octane). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6055 / 6058
页数：4
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