Utility of the adverse outcome pathway concept in drug development

被引：21
作者：
Hartung, Thomas [1 ,2 ]
机构：
[1] Johns Hopkins Bloomberg Sch Publ Hlth, CAAT, Baltimore, MD USA
[2] Univ Konstanz, CAAT, Pharmacol & Toxicol, Constance, Germany
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2017年 / 13卷 / 01期
关键词：
Toxicology for the 21st century; mechanistic toxicology; omics technologies; hazard; chemicals; INTEGRATED TESTING STRATEGIES; HUMAN TOXOME; FOOD; THOUGHT; METABOLOMICS; TOXICOLOGY; TOXICITY;
D O I：
10.1080/17425255.2017.1246535
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1 / 3
页数：3
相关论文
共 15 条
[1]   Quality Assurance of Metabolomics [J].
Bouhifd, Mounir ;
Beger, Richard ;
Flynn, Thomas ;
Guo, Lining ;
Harris, Georgina ;
Hogberg, Helena ;
Kaddurah-Daouk, Rima ;
Kamp, Hennicke ;
Kleensang, Andre ;
Maertens, Alexandra ;
Odwin-DaCosta, Shelly ;
Pamies, David ;
Robertson, Donald ;
Smirnova, Lena ;
Sun, Jinchun ;
Zhao, Liang ;
Hartung, Thomas .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2015, 32 (04) :319-326
[2]   The Human Toxome Project [J].
Bouhifd, Mounir ;
Andersen, Melvin E. ;
Baghdikian, Christina ;
Boekelheide, Kim ;
Crofton, Kevin M. ;
Fornace, Albert J., Jr. ;
Kleensang, Andre ;
Li, Henghong ;
Livi, Carolina ;
Maertens, Alexandra ;
McMullen, Patrick D. ;
Rosenberg, Michael ;
Thomas, Russell ;
Vantangoli, Marguerite ;
Yager, James D. ;
Zhao, Liang ;
Hartung, Thomas .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2015, 32 (02) :112-124
[3]   Review: Toxicometabolomics [J].
Bouhifd, Mounir ;
Hartung, Thomas ;
Hogberg, Helena T. ;
Kleensang, Andre ;
Zhao, Liang .
JOURNAL OF APPLIED TOXICOLOGY, 2013, 33 (12) :1365-1383
[4]  
Hartung T, 2008, ALTEX-ALTERN TIEREXP, V25, P3
[5]  
Hartung T, 2007, ALTEX-ALTERN TIEREXP, V24, P143
[6]   Mechanistic Validation [J].
Hartung, Thomas ;
Hoffmann, Sebastian ;
Stephens, Martin .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2013, 30 (02) :119-130
[7]   Food for Thought ... Integrated Testing Strategies for Safety Assessments [J].
Hartung, Thomas ;
Luechtefeld, Tom ;
Maertens, Alexandra ;
Kleensang, Andre .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2013, 30 (01) :3-18
[8]   Systems Toxicology [J].
Hartung, Thomas ;
van Vliet, Erwin ;
Jaworska, Joanna ;
Bonilla, Leo ;
Skinner, Nigel ;
Thomas, Russell .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2012, 29 (02) :119-128
[9]   Food for Thought ... on Mapping the Human Toxome [J].
Hartung, Thomas ;
McBride, Mary .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2011, 28 (02) :83-93
[10]   Pathways of Toxicity [J].
Kleensang, Andre ;
Maertens, Alexandra ;
Rosenberg, Michael ;
Fitzpatrick, Suzanne ;
Lamb, Justin ;
Auerbach, Scott ;
Brennan, Richard ;
Crofton, Kevin M. ;
Gordon, Ben ;
Fornace, Albert J., Jr. ;
Gaido, Kevin ;
Gerhold, David ;
Haw, Robin ;
Henney, Adrian ;
Ma'ayan, Avi ;
McBride, Mary ;
Monti, Stefano ;
Ochs, Michael F. ;
Pandey, Akhilesh ;
Sharan, Roded ;
Stierum, Rob ;
Tugendreich, Stuart ;
Willett, Catherine ;
Wittwehr, Clemens ;
Xia, Jianguo ;
Patton, Geoffrey W. ;
Arvidson, Kirk ;
Bouhifd, Mounir ;
Hogberg, Helena T. ;
Luechtefeld, Thomas ;
Smirnova, Lena ;
Zhao, Liang ;
Adeleye, Yeyejide ;
Kanehisa, Minoru ;
Carmichael, Paul ;
Andersen, Melvin E. ;
Hartung, Thomas .
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 2014, 31 (01) :53-61
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