Combinatorial complexity in chromatin structure and function: revisiting the histone code

被引:193
作者
Rando, Oliver J. [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA
关键词
SACCHAROMYCES-CEREVISIAE; GENE REPRESSION; ANTISENSE RNAS; S; CEREVISIAE; HUMAN GENOME; ACETYLATION; METHYLATION; TRANSCRIPTION; BROMODOMAIN; NUCLEOSOME;
D O I
10.1016/j.gde.2012.02.013
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Covalent modifications of histone proteins play key roles in transcription, DNA repair, recombination, and other such processes. Over a hundred histone modifications have been described, and a popular idea in the field is that the function of a single histone mark cannot be understood without understanding its combinatorial co-occurrence with other marks, an idea generally called the 'histone code hypothesis.' This idea is hotly debated, with increasing biochemical evidence for chromatin regulatory factors that bind to specific histone modification combinations, but functional and localization studies finding minimal combinatorial complexity in histone modification patterns. This review will focus on these contrasting results, and will briefly touch on possible ways to reconcile these conflicting views.
引用
收藏
页码:148 / 155
页数:8
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