共 52 条
Combinatorial complexity in chromatin structure and function: revisiting the histone code
被引:193
作者:

Rando, Oliver J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA
机构:
[1] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA
关键词:
SACCHAROMYCES-CEREVISIAE;
GENE REPRESSION;
ANTISENSE RNAS;
S;
CEREVISIAE;
HUMAN GENOME;
ACETYLATION;
METHYLATION;
TRANSCRIPTION;
BROMODOMAIN;
NUCLEOSOME;
D O I:
10.1016/j.gde.2012.02.013
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Covalent modifications of histone proteins play key roles in transcription, DNA repair, recombination, and other such processes. Over a hundred histone modifications have been described, and a popular idea in the field is that the function of a single histone mark cannot be understood without understanding its combinatorial co-occurrence with other marks, an idea generally called the 'histone code hypothesis.' This idea is hotly debated, with increasing biochemical evidence for chromatin regulatory factors that bind to specific histone modification combinations, but functional and localization studies finding minimal combinatorial complexity in histone modification patterns. This review will focus on these contrasting results, and will briefly touch on possible ways to reconcile these conflicting views.
引用
收藏
页码:148 / 155
页数:8
相关论文
共 52 条
[1]
High-resolution profiling of histone methylations in the human genome
[J].
Barski, Artern
;
Cuddapah, Suresh
;
Cui, Kairong
;
Roh, Tae-Young
;
Schones, Dustin E.
;
Wang, Zhibin
;
Wei, Gang
;
Chepelev, Iouri
;
Zhao, Keji
.
CELL,
2007, 129 (04)
:823-837

Barski, Artern
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Cuddapah, Suresh
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Cui, Kairong
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Roh, Tae-Young
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Schones, Dustin E.
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Wang, Zhibin
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Wei, Gang
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Chepelev, Iouri
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

Zhao, Keji
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA
[2]
A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae
[J].
Berretta, Julia
;
Pinskaya, Marina
;
Morillon, Antonin
.
GENES & DEVELOPMENT,
2008, 22 (05)
:615-626

Berretta, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

Pinskaya, Marina
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

Morillon, Antonin
论文数: 0 引用数: 0
h-index: 0
机构:
CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France
[3]
Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae
[J].
Camblong, Jurgi
;
Beyrouthy, Nissrine
;
Guffanti, Elisa
;
Schlaepfer, Guillaume
;
Steinmetz, Lars M.
;
Stutz, Francoise
.
GENES & DEVELOPMENT,
2009, 23 (13)
:1534-1545

Camblong, Jurgi
论文数: 0 引用数: 0
h-index: 0
机构: Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

Beyrouthy, Nissrine
论文数: 0 引用数: 0
h-index: 0
机构: Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

Guffanti, Elisa
论文数: 0 引用数: 0
h-index: 0
机构: Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

Schlaepfer, Guillaume
论文数: 0 引用数: 0
h-index: 0
机构: Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

Steinmetz, Lars M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

Stutz, Francoise
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland
[4]
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription
[J].
Carrozza, MJ
;
Li, B
;
Florens, L
;
Suganuma, T
;
Swanson, SK
;
Lee, KK
;
Shia, WJ
;
Anderson, S
;
Yates, J
;
Washburn, MP
;
Workman, JL
.
CELL,
2005, 123 (04)
:581-592

Carrozza, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Li, B
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Florens, L
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Suganuma, T
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Swanson, SK
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Lee, KK
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Shia, WJ
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Anderson, S
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Yates, J
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Washburn, MP
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA

Workman, JL
论文数: 0 引用数: 0
h-index: 0
机构: Stowers Inst Med Res, Kansas City, MO 64110 USA
[5]
Chromatin- and Transcription-Related Factors Repress Transcription from within Coding Regions throughout the Saccharomyces cerevisiae Genome
[J].
Cheung, Vanessa
;
Chua, Gordon
;
Batada, Nizar N.
;
Landry, Christian R.
;
Michnick, Stephen W.
;
Hughes, Timothy R.
;
Winston, Fred
.
PLOS BIOLOGY,
2008, 6 (11)
:2550-2562

Cheung, Vanessa
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Chua, Gordon
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Banting & Best Dept Med Res, Toronto, ON, Canada Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Batada, Nizar N.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Landry, Christian R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montreal, Dept Biochim, Montreal, PQ H3C 3J7, Canada
Univ Montreal, Ctr Robert Cedergren, Montreal, PQ H3C 3J7, Canada Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Michnick, Stephen W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Montreal, Dept Biochim, Montreal, PQ H3C 3J7, Canada
Univ Montreal, Ctr Robert Cedergren, Montreal, PQ H3C 3J7, Canada Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Hughes, Timothy R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Toronto, Banting & Best Dept Med Res, Toronto, ON, Canada Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

Winston, Fred
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[6]
Critical role for the histone H4N terminus in nucleosome remodeling by ISWI
[J].
Clapier, CR
;
Längst, G
;
Corona, DFV
;
Becker, PB
;
Nightingale, KP
.
MOLECULAR AND CELLULAR BIOLOGY,
2001, 21 (03)
:875-883

Clapier, CR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany

Längst, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany

Corona, DFV
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany

Becker, PB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany

Nightingale, KP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Munich, Adolf Butenandt Inst, D-80336 Munich, Germany
[7]
Modulation of ISWI function by site-specific histone acetylation
[J].
Corona, DFV
;
Clapier, CR
;
Becker, PB
;
Tamkun, JW
.
EMBO REPORTS,
2002, 3 (03)
:242-247

Corona, DFV
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

Clapier, CR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

Becker, PB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

Tamkun, JW
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA
[8]
Structure and ligand of a histone acetyltransferase bromodomain
[J].
Dhalluin, C
;
Carlson, JE
;
Zeng, L
;
He, C
;
Aggarwal, AK
;
Zhou, MM
.
NATURE,
1999, 399 (6735)
:491-496

Dhalluin, C
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

Carlson, JE
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

Zeng, L
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

He, C
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

Aggarwal, AK
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA

Zhou, MM
论文数: 0 引用数: 0
h-index: 0
机构:
CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA CUNY Mt Sinai Sch Med, Dept Physiol & Biophys, Struct Biol Program, New York, NY 10029 USA
[9]
Genomic characterization reveals a simple histone H4 acetylation code
[J].
Dion, MF
;
Altschuler, SJ
;
Wu, LF
;
Rando, OJ
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2005, 102 (15)
:5501-5506

Dion, MF
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA

Altschuler, SJ
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA

Wu, LF
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA

Rando, OJ
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA Harvard Univ, Bauer Ctr Genom Res, Cambridge, MA 02138 USA
[10]
DSIF and RNA Polymerase II CTD Phosphorylation Coordinate the Recruitment of Rpd3S to Actively Transcribed Genes
[J].
Drouin, Simon
;
Laramee, Louise
;
Jacques, Pierre-Etienne
;
Forest, Audrey
;
Bergeron, Maxime
;
Robert, Francois
.
PLOS GENETICS,
2010, 6 (10)
:1-12

Drouin, Simon
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

Laramee, Louise
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

Jacques, Pierre-Etienne
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

Forest, Audrey
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

Bergeron, Maxime
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

Robert, Francois
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada
Univ Montreal, Fac Med, Dept Med, Montreal, PQ H3C 3J7, Canada Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada