Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila

被引:28
作者
Wu, Shun-Fan [1 ,2 ]
Ja, Ya-Long [1 ]
Zhang, Yi-jie [1 ]
Yang, Chung-Hui [2 ]
机构
[1] Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
[2] Duke Univ, Dept Neurobiol, Durham, NC 27706 USA
基金
中国国家自然科学基金;
关键词
DECISION-MAKING; UV-LIGHT; TASTE; HEARING; RECEPTORS; BEHAVIOR; SYSTEM; MELANOGASTER; PREFERENCE; AVOIDANCE;
D O I
10.7554/eLife.46165
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, females switch from preferring the softer option for egg-laying when both options are sugar free to being indifferent between them when both contain sucrose. Such sucrose-induced indifference between options of different hardness requires functional sweet neurons, and, curiously, the Transmembrane Channel-like (TMC)-expressing mechanosensitive neurons that have been previously shown to promote discrimination of substrate hardness during feeding. Further, axons of sweet neurons directly contact axons of TMC-expressing neurons in the brain and stimulation of sweet neurons increases Ca2+ influx into axons of TMC-expressing neurons. These results uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions.
引用
收藏
页数:24
相关论文
共 52 条
[11]   Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila [J].
Gong, ZF ;
Son, WS ;
Chung, YD ;
Kim, JW ;
Shin, DW ;
McClung, CA ;
Lee, Y ;
Lee, HW ;
Chang, DJ ;
Kaang, BK ;
Cho, HW ;
Oh, U ;
Hirsh, J ;
Kernan, MJ ;
Kim, CS .
JOURNAL OF NEUROSCIENCE, 2004, 24 (41) :9059-9066
[12]   Motor Control in a Drosophila Taste Circuit [J].
Gordon, Michael D. ;
Scott, Kristin .
NEURON, 2009, 61 (03) :373-384
[13]   High Throughput Assay to Examine Egg-Laying Preferences of Individual Drosophila melanogaster [J].
Gou, Bin ;
Zhu, Edward ;
He, Ruo ;
Stern, Ulrich ;
Yang, Chung-Hui .
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2016, (109)
[14]   Mechanosensitive Neurons on the Internal Reproductive Tract Contribute to Egg-Laying-Induced Acetic Acid Attraction in Drosophila [J].
Gou, Bin ;
Liu, Ying ;
Guntur, Ananya R. ;
Stern, Ulrich ;
Yang, Chung-Hui .
CELL REPORTS, 2014, 9 (02) :522-530
[15]   H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying [J].
Guntur, Ananya R. ;
Gou, Bin ;
Gu, Pengyu ;
He, Ruo ;
Stern, Ulrich ;
Xiang, Yang ;
Yang, Chung-Hui .
GENETICS, 2017, 205 (02) :749-759
[16]   Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2 [J].
Guntur, Ananya R. ;
Gu, Pengyu ;
Takle, Kendra ;
Chen, Jingyi ;
Xiang, Yang ;
Yang, Chung-Hui .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (42) :E5753-E5761
[17]   Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion [J].
Guo, Yanmeng ;
Wang, Yuping ;
Zhang, Wei ;
Meltzer, Shan ;
Zanini, Damiano ;
Yu, Yue ;
Li, Jiefu ;
Cheng, Tong ;
Guo, Zhenhao ;
Wang, Qingxiu ;
Jacobs, Julie S. ;
Sharma, Yashoda ;
Eberl, Daniel F. ;
Goepfert, Martin C. ;
Jan, Lily Yeh ;
Jan, Yuh Nung ;
Wang, Zuoren .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (26) :7243-7248
[18]   An internal thermal sensor controlling temperature preference in Drosophila [J].
Hamada, Fumika N. ;
Rosenzweig, Mark ;
Kang, Kyeongjin ;
Pulver, Stefan R. ;
Ghezzi, Alfredo ;
Jegla, Timothy J. ;
Garrity, Paul A. .
NATURE, 2008, 454 (7201) :217-U55
[19]   Mechanosensory neurons control sweet sensing in Drosophila [J].
Jeong, Yong Taek ;
Oh, Soo Min ;
Shim, Jaewon ;
Seo, Jeong Taeg ;
Kwon, Jae Young ;
Moon, Seok Jun .
NATURE COMMUNICATIONS, 2016, 7
[20]   Tissue-Specific Activation of a Single Gustatory Receptor Produces Opposing Behavioral Responses in Drosophila [J].
Joseph, Ryan M. ;
Heberlein, Ulrike .
GENETICS, 2012, 192 (02) :521-+