Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila

被引:28
作者
Wu, Shun-Fan [1 ,2 ]
Ja, Ya-Long [1 ]
Zhang, Yi-jie [1 ]
Yang, Chung-Hui [2 ]
机构
[1] Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
[2] Duke Univ, Dept Neurobiol, Durham, NC 27706 USA
基金
中国国家自然科学基金;
关键词
DECISION-MAKING; UV-LIGHT; TASTE; HEARING; RECEPTORS; BEHAVIOR; SYSTEM; MELANOGASTER; PREFERENCE; AVOIDANCE;
D O I
10.7554/eLife.46165
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, females switch from preferring the softer option for egg-laying when both options are sugar free to being indifferent between them when both contain sucrose. Such sucrose-induced indifference between options of different hardness requires functional sweet neurons, and, curiously, the Transmembrane Channel-like (TMC)-expressing mechanosensitive neurons that have been previously shown to promote discrimination of substrate hardness during feeding. Further, axons of sweet neurons directly contact axons of TMC-expressing neurons in the brain and stimulation of sweet neurons increases Ca2+ influx into axons of TMC-expressing neurons. These results uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions.
引用
收藏
页数:24
相关论文
共 52 条
[1]   The making of a pest: the evolution of a fruit-penetrating ovipositor in Drosophila suzukii and related species [J].
Atallah, Joel ;
Teixeira, Lisa ;
Salazar, Raul ;
Zaragoza, George ;
Kopp, Artyom .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2014, 281 (1781)
[2]   Competing dopamine neurons drive oviposition choice for ethanol in Drosophila [J].
Azanchi, Reza ;
Kaun, Karla R. ;
Heberlein, Ulrike .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (52) :21153-21158
[3]  
Branson K, 2009, NAT METHODS, V6, P451, DOI [10.1038/NMETH.1328, 10.1038/nmeth.1328]
[4]   Abdominal-B Neurons Control Drosophila Virgin Female Receptivity [J].
Bussell, Jennifer J. ;
Yapici, Nilay ;
Zhang, Stephen X. ;
Dickson, Barry J. ;
Vosshall, Leslie B. .
CURRENT BIOLOGY, 2014, 24 (14) :1584-1595
[5]   The molecular basis for water taste in Drosophila [J].
Cameron, Peter ;
Hiroi, Makoto ;
Ngai, John ;
Scott, Kristin .
NATURE, 2010, 465 (7294) :91-U101
[6]   Ultrasensitive fluorescent proteins for imaging neuronal activity [J].
Chen, Tsai-Wen ;
Wardill, Trevor J. ;
Sun, Yi ;
Pulver, Stefan R. ;
Renninger, Sabine L. ;
Baohan, Amy ;
Schreiter, Eric R. ;
Kerr, Rex A. ;
Orger, Michael B. ;
Jayaraman, Vivek ;
Looger, Loren L. ;
Svoboda, Karel ;
Kim, Douglas S. .
NATURE, 2013, 499 (7458) :295-+
[7]   Two Gr genes underlie sugar reception in Drosophila [J].
Dahanukar, Anupama ;
Lei, Ya-Ting ;
Kwon, Jae Young ;
Carlson, John R. .
NEURON, 2007, 56 (03) :503-516
[8]   Spatially restricted expression of candidate taste receptors in the Drosophila gustatory system [J].
Dunipace, L ;
Meister, S ;
McNealy, C ;
Amrein, H .
CURRENT BIOLOGY, 2001, 11 (11) :822-835
[9]   GFP reconstitution across synaptic partners (GRASP) defines cell contacts and Synapses in living nervous systems [J].
Feinberg, Evan H. ;
VanHoven, Miri K. ;
Bendesky, Andres ;
Wang, George ;
Fetter, Richard D. ;
Shen, Kang ;
Bargmannl, Cornelia I. .
NEURON, 2008, 57 (03) :353-363
[10]   Drosophila Sugar Receptors in Sweet Taste Perception, Olfaction, and Internal Nutrient Sensing [J].
Fujii, Shinsuke ;
Yavuz, Ahmet ;
Slone, Jesse ;
Jagge, Christopher ;
Song, Xiangyu ;
Amrein, Hubert .
CURRENT BIOLOGY, 2015, 25 (05) :621-627