Sweet neurons inhibit texture discrimination by signaling TMC-expressing mechanosensitive neurons in Drosophila
被引:28
作者:
Wu, Shun-Fan
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机构:
Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
Duke Univ, Dept Neurobiol, Durham, NC 27706 USANanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
Wu, Shun-Fan
[1
,2
]
Ja, Ya-Long
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机构:
Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R ChinaNanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
Ja, Ya-Long
[1
]
Zhang, Yi-jie
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h-index: 0
机构:
Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R ChinaNanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
Zhang, Yi-jie
[1
]
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机构:
Yang, Chung-Hui
[2
]
机构:
[1] Nanjing Agr Univ, Coll Plant Protect, State & Local Joint Engn Res Ctr Green Pesticide, Nanjing, Jiangsu, Peoples R China
[2] Duke Univ, Dept Neurobiol, Durham, NC 27706 USA
Integration of stimuli of different modalities is an important but incompletely understood process during decision making. Here, we show that Drosophila are capable of integrating mechanosensory and chemosensory information of choice options when deciding where to deposit their eggs. Specifically, females switch from preferring the softer option for egg-laying when both options are sugar free to being indifferent between them when both contain sucrose. Such sucrose-induced indifference between options of different hardness requires functional sweet neurons, and, curiously, the Transmembrane Channel-like (TMC)-expressing mechanosensitive neurons that have been previously shown to promote discrimination of substrate hardness during feeding. Further, axons of sweet neurons directly contact axons of TMC-expressing neurons in the brain and stimulation of sweet neurons increases Ca2+ influx into axons of TMC-expressing neurons. These results uncover one mechanism by which Drosophila integrate taste and tactile information when deciding where to deposit their eggs and reveal that TMC-expressing neurons play opposing roles in hardness discrimination in two different decisions.
机构:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Univ Calif San Francisco, Program Neurosci, San Francisco, CA 94158 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USAUniv Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Azanchi, Reza
;
Kaun, Karla R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Univ Calif San Francisco, Program Neurosci, San Francisco, CA 94158 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USAUniv Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Kaun, Karla R.
;
Heberlein, Ulrike
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Univ Calif San Francisco, Program Neurosci, San Francisco, CA 94158 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USAUniv Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Bussell, Jennifer J.
;
Yapici, Nilay
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Yapici, Nilay
;
Zhang, Stephen X.
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h-index: 0
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Zhang, Stephen X.
;
Dickson, Barry J.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Dickson, Barry J.
;
Vosshall, Leslie B.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Cameron, Peter
;
Hiroi, Makoto
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Hiroi, Makoto
;
Ngai, John
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Funct Genom Lab, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Ngai, John
;
Scott, Kristin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Chen, Tsai-Wen
;
Wardill, Trevor J.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Wardill, Trevor J.
;
Sun, Yi
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h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Sun, Yi
;
Pulver, Stefan R.
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机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Pulver, Stefan R.
;
Renninger, Sabine L.
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h-index: 0
机构:
Champalimaud Ctr Unknown, Champalimaud Neurosci Programme, P-1400038 Lisbon, PortugalHoward Hughes Med Inst, Ashburn, VA 20147 USA
Renninger, Sabine L.
;
Baohan, Amy
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USA
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Baohan, Amy
;
Schreiter, Eric R.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Schreiter, Eric R.
;
Kerr, Rex A.
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h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Kerr, Rex A.
;
Orger, Michael B.
论文数: 0引用数: 0
h-index: 0
机构:
Champalimaud Ctr Unknown, Champalimaud Neurosci Programme, P-1400038 Lisbon, PortugalHoward Hughes Med Inst, Ashburn, VA 20147 USA
Orger, Michael B.
;
Jayaraman, Vivek
论文数: 0引用数: 0
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机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Jayaraman, Vivek
;
Looger, Loren L.
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机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Looger, Loren L.
;
Svoboda, Karel
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h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Svoboda, Karel
;
Kim, Douglas S.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
机构:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Univ Calif San Francisco, Program Neurosci, San Francisco, CA 94158 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USAUniv Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Azanchi, Reza
;
Kaun, Karla R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Univ Calif San Francisco, Program Neurosci, San Francisco, CA 94158 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USAUniv Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Kaun, Karla R.
;
Heberlein, Ulrike
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
Univ Calif San Francisco, Program Neurosci, San Francisco, CA 94158 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USAUniv Calif San Francisco, Dept Anat, San Francisco, CA 94158 USA
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Bussell, Jennifer J.
;
Yapici, Nilay
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Yapici, Nilay
;
Zhang, Stephen X.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Zhang, Stephen X.
;
Dickson, Barry J.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Dickson, Barry J.
;
Vosshall, Leslie B.
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
Howard Hughes Med Inst, Ashburn, VA 20147 USARockefeller Univ, Lab Neurogenet & Behav, New York, NY 10065 USA
机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Cameron, Peter
;
Hiroi, Makoto
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Hiroi, Makoto
;
Ngai, John
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Funct Genom Lab, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Ngai, John
;
Scott, Kristin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USAUniv Calif Berkeley, Dept Mol & Cell Biol, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Chen, Tsai-Wen
;
Wardill, Trevor J.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Wardill, Trevor J.
;
Sun, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Sun, Yi
;
Pulver, Stefan R.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Pulver, Stefan R.
;
Renninger, Sabine L.
论文数: 0引用数: 0
h-index: 0
机构:
Champalimaud Ctr Unknown, Champalimaud Neurosci Programme, P-1400038 Lisbon, PortugalHoward Hughes Med Inst, Ashburn, VA 20147 USA
Renninger, Sabine L.
;
Baohan, Amy
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USA
Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Baohan, Amy
;
Schreiter, Eric R.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Schreiter, Eric R.
;
Kerr, Rex A.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Kerr, Rex A.
;
Orger, Michael B.
论文数: 0引用数: 0
h-index: 0
机构:
Champalimaud Ctr Unknown, Champalimaud Neurosci Programme, P-1400038 Lisbon, PortugalHoward Hughes Med Inst, Ashburn, VA 20147 USA
Orger, Michael B.
;
Jayaraman, Vivek
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Jayaraman, Vivek
;
Looger, Loren L.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Looger, Loren L.
;
Svoboda, Karel
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA
Svoboda, Karel
;
Kim, Douglas S.
论文数: 0引用数: 0
h-index: 0
机构:
Howard Hughes Med Inst, Ashburn, VA 20147 USAHoward Hughes Med Inst, Ashburn, VA 20147 USA