Splenic FDG uptake predicts poor prognosis in patients with unresectable cholangiocarcinoma

被引:19
作者
Pak, K. [1 ,3 ]
Kim, S. -J. [1 ,3 ]
Kim, I. J. [1 ,3 ]
Kim, D. U. [2 ,3 ]
Kim, K. [1 ,3 ]
Kim, H. [1 ,3 ]
Kim, S. J. [1 ,3 ]
机构
[1] Pusan Natl Univ Hosp, Dept Nucl Med, Pusan, South Korea
[2] Pusan Natl Univ Hosp, Dept Internal Med, Pusan, South Korea
[3] Pusan Natl Univ Hosp, Med Res Inst, Pusan, South Korea
来源
NUKLEARMEDIZIN-NUCLEAR MEDICINE | 2014年 / 53卷 / 02期
关键词
PET; cholangiocarcinoma; spleen; EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; C-REACTIVE PROTEIN; HILAR CHOLANGIOCARCINOMA; CANCER; INTERLEUKIN-6; DIAGNOSIS; SURVIVAL; PET; INFLAMMATION; INFECTION;
D O I
10.3413/Nukmed-0566-13-03
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Aim: Diffuse splenic F-18-Fluorodeoxyglucose (FDG) uptake has shown to be associated with concurrent inflammation. We evaluated the prognostic value of diffuse splenic FDG uptake for predicting prognosis in cholangiocarcinoma patients. Patients, methods:; Sixty-four patients with unresectable cholangiocarcinoma performed Positron emission tomography/computed tomography (PET/CT) using FDG between July 2009 and April 2012. Patients were divided into two groups according to splenic FDG uptake relative to hepatic FDG uptake. Eleven patients showing splenic FDG uptake exceeding hepatic uptake were included in group A, while 53 patients With hepatic FDG uptake exceeding splenic uptake were included in group B. Prognostic factors for overall survival were evaluated using log-rank test. Variables with a probability of less than or equal to 0.1 on univariate analysis were considered as possible independent factors. Cox-proportional hazards model was used to analyze univariate and multivariate analysis. Results: Mean standardized uptake value of the liver (Liver SUVmean)/Spleen SUVmean (L/S) ratio <1 (p = 0.0034), WBC > 10000 (p = 0.1155) and CEA >30 (p = 0.0946) were predictors of overall survival on univariate analysis. In a subsequent multivariate analysis, L/S ratio <1 remained a significant independent predictor of poor prognosis (HR 6.0153, 95% Cl, 1.7193-21.0460, p = 0.0052). Conclusion: Our study has shown that splenic FDG uptake could be a predictor of overall survival of unresectable cholangiocarcinoma patients.
引用
收藏
页码:26 / 31
页数:6
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