Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - Are they beneficial to the host?

被引：20

作者：

Bryant-Hudson, Katie ^{[1
]}

Conrady, Christopher D. ^{[2
]}

Carr, Daniel J. J. ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA

来源：

PROGRESS IN RETINAL AND EYE RESEARCH | 2013年 / 36卷

关键词：

Virus; Cornea; Lymphatic vessel; Innate immunity; Type I IFN; HERPES-SIMPLEX-VIRUS; ENDOTHELIAL GROWTH-FACTOR; TOLL-LIKE RECEPTORS; HUMAN LEUKOCYTE INTERFERON; INNATE IMMUNE SENSOR; CYTOSOLIC DNA SENSOR; CYCLIC-DI-GMP; RIG-I; DENDRITIC CELLS; SIGNALING PATHWAYS;

D O I：

10.1016/j.preteyeres.2013.06.003

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Herpes simplex virus type I (HSV-1) is a highly successful pathogen that can result in significant human morbidity. Within the cornea, it was thought the initial recognition of the pathogen was through Toll-like receptors expressed on/in resident cells that then elicit pro-inflammatory cytokine production, activation of anti-viral pathways, and recruitment of leukocytes. However, our lab has uncovered a novel, TLR-independent innate sensor that supersedes TLR induction of anti-viral pathways following HSV-1 infection. In addition, we have also found HSV-1 induces the genesis of lymphatic vessels into the cornea proper by a mechanism independent of TLRs and unique in the field of neovascularization. This review will focus on these two innate immune events during acute HSV-1 infection of the cornea. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：281 / 291

页数：11

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