Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - Are they beneficial to the host?

被引:17
作者
Bryant-Hudson, Katie [1 ]
Conrady, Christopher D. [2 ]
Carr, Daniel J. J. [1 ,2 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73104 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA
关键词
Virus; Cornea; Lymphatic vessel; Innate immunity; Type I IFN; HERPES-SIMPLEX-VIRUS; ENDOTHELIAL GROWTH-FACTOR; TOLL-LIKE RECEPTORS; HUMAN LEUKOCYTE INTERFERON; INNATE IMMUNE SENSOR; CYTOSOLIC DNA SENSOR; CYCLIC-DI-GMP; RIG-I; DENDRITIC CELLS; SIGNALING PATHWAYS;
D O I
10.1016/j.preteyeres.2013.06.003
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Herpes simplex virus type I (HSV-1) is a highly successful pathogen that can result in significant human morbidity. Within the cornea, it was thought the initial recognition of the pathogen was through Toll-like receptors expressed on/in resident cells that then elicit pro-inflammatory cytokine production, activation of anti-viral pathways, and recruitment of leukocytes. However, our lab has uncovered a novel, TLR-independent innate sensor that supersedes TLR induction of anti-viral pathways following HSV-1 infection. In addition, we have also found HSV-1 induces the genesis of lymphatic vessels into the cornea proper by a mechanism independent of TLRs and unique in the field of neovascularization. This review will focus on these two innate immune events during acute HSV-1 infection of the cornea. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:281 / 291
页数:11
相关论文
共 125 条
  • [1] Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
    Alekseev, Oleg
    Tran, Anh H.
    Azizkhan-Clifford, Jane
    [J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2012, (69):
  • [2] Corneal avascularity is due to soluble VEGF receptor-1
    Ambati, Balamurali K.
    Nozaki, Miho
    Singh, Nirbhai
    Takeda, Atsunobu
    Jani, Pooja D.
    Suthar, Tushar
    Albuquerque, Romulo J. C.
    Richter, Elizabeth
    Sakurai, Eiji
    Newcomb, Michael T.
    Kleinman, Mark E.
    Caldwell, Ruth B.
    Lin, Qing
    Ogura, Yuichiro
    Orecchia, Angela
    Samuelson, Don A.
    Agnew, Dalen W.
    St. Leger, Judy
    Green, W. Richard
    Mahasreshti, Parameshwar J.
    Curiel, David T.
    Kwan, Donna
    Marsh, Helene
    Ikeda, Sakae
    Leiper, Lucy J.
    Collinson, J. Martin
    Bogdanovich, Sasha
    Khurana, Tejvir S.
    Shibuya, Masabumi
    Baldwin, Megan E.
    Ferrara, Napoleone
    Gerber, Hans-Peter
    De Falco, Sandro
    Witta, Jassir
    Baffi, Judit Z.
    Raisler, Brian J.
    Ambati, Jayakrishna
    [J]. NATURE, 2006, 443 (7114) : 993 - 997
  • [3] Nucleic Acid Recognition by the Innate Immune System
    Barbalat, Roman
    Ewald, Sarah E.
    Mouchess, Maria L.
    Barton, Gregory M.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 : 185 - 214
  • [4] Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses
    Barber, Glen N.
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2011, 23 (01) : 10 - 20
  • [5] Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Bedoui, Sammy
    Whitney, Paul G.
    Waithman, Jason
    Eidsmo, Liv
    Wakim, Linda
    Caminschi, Irina
    Allan, Rhys S.
    Wojtasiak, Magdalena
    Shortman, Ken
    Carbone, Francis R.
    Brooks, Andrew G.
    Heath, William R.
    [J]. NATURE IMMUNOLOGY, 2009, 10 (05) : 488 - 495
  • [6] Mice transgenic for IL-1 receptor antagonist protein are resistant to herpetic stromal keratitis: Possible role for IL-1 in herpetic stromal keratitis pathogenesis
    Biswas, PS
    Banerjee, K
    Kim, B
    Rouse, BT
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (06) : 3736 - 3744
  • [7] Novel anti(lymph)angiogenic treatment strategies for corneal and ocular surface diseases
    Bock, Felix
    Maruyama, Kazuichi
    Regenfuss, Birgit
    Hos, Deniz
    Steven, Philipp
    Heindl, Ludwig M.
    Cursiefen, Claus
    [J]. PROGRESS IN RETINAL AND EYE RESEARCH, 2013, 34 : 89 - 124
  • [8] INTERFERON-ALPHA INCREASES THE FREQUENCY OF INTERFERON-GAMMA-PRODUCING HUMAN CD4+ T-CELLS
    BRINKMANN, V
    GEIGER, T
    ALKAN, S
    HEUSSER, CH
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) : 1655 - 1663
  • [9] Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    Broz, Petr
    Newton, Kim
    Lamkanfi, Mohamed
    Mariathasan, Sanjeev
    Dixit, Vishva M.
    Monack, Denise M.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (08) : 1745 - 1755
  • [10] Bryant-Hudson K. M., 2013, AM J PATHOL IN PRESS