Concurrent JAK2-Positive Myeloproliferative Disorder and Chronic Myelogenous Leukemia: A Novel Entity? A Case Report With Review of the Literature

被引：21

作者：

Bader, Gilbert ^{[1
]}

Dreiling, Bernard ^{[2
]}

机构：

[1] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA

[2] GV Montgomery VA Med Ctr, Jackson, MS USA

来源：

JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS | 2019年 / 7卷

关键词：

myeloproliferative disorder; chronic myelogenous leukemia; JAK2; mutation; BCR-ABL translocation; CHRONIC MYELOID-LEUKEMIA; BCR-ABL TRANSLOCATION; JAK2 V617F MUTATION; POLYCYTHEMIA-VERA; JAK2V617F MUTATION; JAK2-V617F MUTATION; JAK2(V617F) MUTATION; PATIENT; EMERGENCE; ACQUISITION;

D O I：

10.1177/2324709619832322

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

JAK2 V617F mutation and BCR-ABL translocation have been considered to be mutually exclusive. However, many cases where both hits coexisted have been reported. We have personally managed a case too. We believe this hybrid entity is underdiagnosed. Thus, we decided to shed light on this "double hit" disease to improve its diagnosis and optimize its treatment. We reviewed the English literature in PubMed since JAK2 discovery. We found 33 cases reported so far. We summarized patient characteristics and analyzed possible interactions between JAK2 and BCR-ABL clones.

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页数：5

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