Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer

被引：28

作者：

Benvenuto, Monica ^{[1
]}

Fantini, Massimo ^{[1
]}

Masuelli, Laura ^{[2
]}

De Smaele, Enrico ^{[2
]}

Zazzeroni, Francesca ^{[3
]}

Tresoldi, Ilaria ^{[1
]}

Calabrese, Giorgio ^{[4
]}

Galvano, Fabio ^{[5
]}

Modesti, Andrea ^{[1
]}

Bei, Roberto ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Clin Sci & Translat Med, I-00133 Rome, Italy

[2] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy

[3] Univ Aquila, Dept Biotechnol & Appl Clin Sci, I-67100 Laquila, Italy

[4] Piemonte Orientale Univ, Dept Biol, Alessandria, Italy

[5] Univ Catania, Dept Drug Sci, Biochem Sect, Catania, Italy

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2013年 / 18卷

关键词：

Polyphenols; ErbB receptor; Hedgehog; NF-kappaB; Cancer; Review; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE-ACTIVITY; NUCLEAR FACTOR KAPPAB; CELL-CYCLE ARREST; DOWN-REGULATION; SONIC-HEDGEHOG; (-)-EPIGALLOCATECHIN GALLATE; INDUCED APOPTOSIS; EPIGALLOCATECHIN GALLATE; PROTEINASES ACTIVITIES;

D O I：

10.2741/4180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carcinogenesis is a multi-step process triggered by cumulative genetic alterations, which drive the progressive transformation of a normal cell into a cancer cell. Among the signal transduction pathways whose crosstalk plays an important role in neoplastic transformation are those mediated by ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) cascade. Polyphenols can be employed to inhibit the growth of cancer cells due to their ability to modulate the activity of multiple targets involved in carcinogenesis through simultaneous direct interaction or modulation of gene expression. This review will describe the cross-talk between ErbB receptors, NF-kappaB and the Hedgehog (HH)/glioma-associated oncogene (GLI) signaling pathways and the potential role of polyphenols in inhibiting this dialogue and the growth of cancer cells.

引用

页码：1291 / 1311

页数：21

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