Synthesis of Functionalized Isoquinolin-1(2H)-ones by Copper-Catalyzed -Arylation of Ketones with 2-Halobenzamides

被引：33
作者：
Shi, Yan [1 ]
Zhu, Xuebin [1 ]
Mao, Haibin [1 ]
Hu, Hongwen [1 ]
Zhu, Chengjian [1 ,2 ]
Cheng, Yixiang [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 35期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
alpha-arylation; copper; heterocycles; isoquinolin-1(2H)-ones; synthetic methods; C-H FUNCTIONALIZATION; FORMING REDUCTIVE ELIMINATION; MONO-ALPHA-ARYLATION; ONE-POT SYNTHESIS; N BOND FORMATION; BIOLOGICAL EVALUATION; ARYL HALIDES; A-ARYLATION; QUINAZOLINONES; DERIVATIVES;
D O I：
10.1002/chem.201301621
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Copper is key: A concise route to isoquinolin-1(2H)-ones from simple and readily available starting materials is provided by an efficient copper-catalyzed annulation of ketones with 2-halobenzamides. The method is applicable to a wide range of ketones containing different functional groups furnishing the products in moderate to excellent yields. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11553 / 11557
页数：5
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