Effects and mechanism of renal denervation on ventricular arrhythmia after acute myocardial infarction in rats

被引：5
作者：
Ye, Jian [3 ]
Xiao, Rongxue [1 ,2 ,3 ]
Wang, Xu [3 ]
He, Ruiqing [3 ]
Liu, Zongjun [1 ,2 ,3 ]
Gao, Junqing [3 ]
机构：
[1] Anhui Med Univ, Shanghai Putuo Cent Sch Clin Med, Shanghai 200062, Peoples R China
[2] Anhui Med Univ, Sch Clin Med 5, Shanghai 200062, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Cardiol, Shanghai 200062, Peoples R China
来源：
BMC CARDIOVASCULAR DISORDERS | 2022年 / 22卷 / 01期
关键词：
Renal denervation; Acute myocardial infarction; Ventricular arrhythmia; Central nervous system; Sympathetic nerve; SYMPATHETIC-NERVE ACTIVITY; IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS; HEART-FAILURE; PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; TACHYCARDIA;
D O I：
10.1186/s12872-022-02980-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
BackgroundRenal denervation (RDN) can reduce ventricular arrhythmia after acute myocardial infarction (AMI), but the mechanism is not clear. The purpose of this study is to study its mechanism. MethodsThirty-two Sprague-Dawley rats were divided into four groups: control group, AMI group, RDN-1d + AMI group, RDN-2w + AMI group. The AMI model was established 1 day after RDN in the RDN-1d + AMI group and 2 weeks after RDN in the RDN-2w + AMI group. At the same time, 8 normal rats were subjected to AMI modelling (the AMI group). The control group consisted of 8 rats without RDN intervention or AMI modelling. ResultsThe study confirmed that RDN can reduce the occurrence of ventricular tachycardia in AMI rats, reduce renal sympathetic nerve discharge, and inhibit the activity of local sympathetic nerves and cell growth factor (NGF) protein expression in the heart after AMI. In addition, RDN decreased the expression of norepinephrine (NE) and glutamate in the hypothalamus,and NE in cerebrospinal fluid, and increased the expression level of gamma aminobutyric acid (GABA) in the hypothalamus after AMI. ConclusionRDN can effectively reduce the occurrence of ventricular arrhythmia after AMI, and its main mechanism may be via the inhibition of central sympathetic nerve discharge.
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页数：10
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