Metagenome-wide analysis of antibiotic resistance genes in a large cohort of human gut microbiota

被引：608

作者：

Hu, Yongfei ^{[1
]}

Yang, Xi ^{[1
]}

Qin, Junjie ^{[2
]}

Lu, Na ^{[1
]}

Cheng, Gong ^{[1
]}

Wu, Na ^{[1
]}

Pan, Yuanlong ^{[1
]}

Li, Jing ^{[1
]}

Zhu, Liying ^{[3
]}

Wang, Xin ^{[3
]}

Meng, Zhiqi ^{[3
]}

Zhao, Fangqing ^{[4
]}

Liu, Di ^{[1
]}

Ma, Juncai ^{[1
]}

Qin, Nan ^{[5
]}

Xiang, Chunsheng ^{[5
]}

Xiao, Yonghong ^{[5
]}

Li, Lanjuan ^{[5
]}

Yang, Huanming ^{[2
]}

Wang, Jian ^{[2
]}

Yang, Ruifu ^{[6
]}

Gao, George F. ^{[1
,7
]}

Wang, Jun ^{[2
]}

Zhu, Baoli ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[2] BGI Shenzhen, Shenzhen 518083, Peoples R China

[3] Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, State Key Lab Breeding Base Zhejiang Sustainable, Hangzhou 310021, Zhejiang, Peoples R China

[4] Chinese Acad Sci, Beijing Inst Life Sci, Computat Genom Lab, Beijing 100101, Peoples R China

[5] Zhejiang Univ, Affiliated Hosp 1, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

[6] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogens & Biosecur, Beijing, Peoples R China

[7] Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth, Beijing 100101, Peoples R China

来源：

NATURE COMMUNICATIONS | 2013年 / 4卷

基金：

中国国家自然科学基金;

关键词：

LONG-TERM IMPACTS; TETRACYCLINE RESISTANCE; GENOME SEQUENCE; ASSOCIATION; BACTERIA; CHINA;

D O I：

10.1038/ncomms3151

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human gut microbiota is a reservoir of antibiotic resistance genes, but little is known about their diversity and richness within the gut. Here we analyse the antibiotic resistance genes of gut microbiota from 162 individuals. We identify a total of 1,093 antibiotic resistance genes and find that Chinese individuals harbour the highest number and abundance of antibiotic resistance genes, followed by Danish and Spanish individuals. Single-nucleotide polymorphism-based analysis indicates that antibiotic resistance genes from the two European populations are more closely related while the Chinese ones are clustered separately. We also confirm high abundance of tetracycline resistance genes with this large cohort study. Our study provides a broad view of antibiotic resistance genes in the human gut microbiota.

引用

页数：7

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