Lumican modulates adipocyte function in obesity-associated type 2 diabetes

被引：4

作者：

Strieder-Barboza ^{[1
,2
,3
]}

Flesher, Carmen G. ^{[1
]}

Geletka, Lynn ^{[4
]}

Eichler, Tad ^{[1
]}

Akinleye, Olukemi ^{[1
]}

Ky, Alexander P. ^{[1
]}

Ehlers, Anne N. ^{[1
,5
]}

Lumeng, Carey W. ^{[6
,7
]}

O'Rourke, Robert ^{[1
,5
,8
]}

机构：

[1] Univ Michigan, Dept Surg, Med Sch, Ann Arbor, MI USA

[2] Texas Tech Univ, Dept Vet Sci, Lubbock, TX USA

[3] Texas Tech Univ, Sch Vet Med, Amarillo, TX USA

[4] Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI USA

[5] Vet Affairs Ann Arbor Healthcare Syst, Dept Surg, Ann Arbor, MI USA

[6] Univ Michigan, Grad Program Immunol, Med Sch, Ann Arbor, MI USA

[7] Univ Michigan, Grad Program Cellular & Mol Biol, Med Sch, Ann Arbor, MI USA

[8] Univ Michigan, Taubman Ctr 2210, Dept Surg, Sect Gen Surg, 1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA

来源：

ADIPOCYTE | 2022年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Lumican; adipose tissue; diabetes; insulin resistance; ERK; ADIPOSE-TISSUE; FIBROSIS; DIFFERENTIATION; EXPRESSION;

D O I：

10.1080/21623945.2022.2154112

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from subjects with and without DM, we studied lumican effects on adipocyte function. Lumican was increased in VAT and adipocytes in DM. Lumican knockdown in adipocytes decreased lipolysis and improved adipogenesis and insulin sensitivity in VAT adipocytes in DM, while treatment with human recombinant lumican increased lipolysis and impaired insulin-sensitivity in an ERK-dependent manner. We demonstrate that lumican impairs adipocyte metabolism, partially via ERK signalling, and is a potential target for developing adipose tissue-targeted therapeutics in DM.

引用

页码：665 / 675

页数：11

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