The Management of Pediatric Multiple Sclerosis

被引：11

作者：

Yeh, E. Ann ^{[1
,2
]}

Weinstock-Guttman, Bianca ^{[3
,4
,5
]}

机构：

[1] Univ Toronto, Div Neurol, Demyelinating Disorders Program, Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Pediat Neurol, Toronto, ON M5G 1X8, Canada

[3] SUNY Buffalo, Pediat Multiple Sclerosis Ctr, Buffalo, NY 14260 USA

[4] SUNY Buffalo, Baird Multiple Sclerosis Ctr, Jacobs Neurol Inst, Buffalo, NY 14260 USA

[5] SUNY Buffalo, Dept Neurol, Buffalo, NY 14260 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2012年 / 27卷 / 11期

关键词：

therapies; demyelination; pediatric; multiple sclerosis; QUALITY-OF-LIFE; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; PHASE-II; ADD-ON; PSYCHOSOCIAL FEATURES; GLATIRAMER ACETATE; INTERFERON BETA-1A; ORAL FINGOLIMOD;

D O I：

10.1177/0883073812452785

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Prevention of disability through disease-modifying therapies has been a source of significant attention among clinicians treating children and adolescents with multiple sclerosis (MS). In this article, we will review currently available literature on therapies and the management of pediatric-onset multiple sclerosis, with specific discussion of therapies for acute exacerbations and disease-modifying therapies that may prevent relapses and slow disease progression, and will include a brief discussion of future directions in symptomatic interventions for cognitive decline, fatigue, and depression in children and adolescents with multiple sclerosis. Our article will focus specifically on children and adolescents with relapsing-remitting multiple sclerosis, as 99% of cases of pediatric-onset multiple sclerosis are relapsing-remitting multiple sclerosis.

引用

页码：1384 / 1393

页数：10

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