Cognitive Impairment After Sleep Deprivation Rescued by Transcranial Magnetic Stimulation Application in Octodon degus

被引：17

作者：

Estrada, C. ^{[1
]}

Lopez, D. ^{[1
]}

Conesa, A. ^{[1
]}

Fernandez-Gomez, F. J. ^{[1
]}

Gonzalez-Cuello, A. ^{[1
]}

Toledo, F. ^{[1
]}

Tunez, I. ^{[2
]}

Blin, O. ^{[3
]}

Bordet, R. ^{[4
]}

Richardson, J. C. ^{[5
]}

Fernandez-Villalba, E. ^{[1
]}

Herrero, M. T. ^{[1
]}

机构：

[1] Univ Murcia, Inst Biomed Res Murcia IMIB, Sch Med, Clin & Expt Neurosci, E-30100 Murcia, Spain

[2] Univ Cordoba, Res Network Ageing & Fragile RETICEF, Dept Biochem & Mol Biol, Fac Med,Maimonides Inst Biomed Res Cordoba IMIBIC, Cordoba, Spain

[3] Aix Marseille Univ, Dept Pharmacol, Marseille, France

[4] Univ Lille North, Dept Med Pharmacol, F-59045 Lille, France

[5] GlaxoSmithKline R&D, Neurosci Therapeut Area, Stevenage SG1 2NY, Herts, England

来源：

NEUROTOXICITY RESEARCH | 2015年 / 28卷 / 04期

关键词：

Sleep deprivation; Transcranial magnetic stimulation (TMS); Octodon degus; Learning; Memory; ALZHEIMERS-DISEASE; MEMORY CONSOLIDATION; HUNTINGTONS-DISEASE; OBJECT RECOGNITION; DRUG DISCOVERY; WORKING-MEMORY; SPATIAL MEMORY; DENTATE GYRUS; IN-VIVO; RATS;

D O I：

10.1007/s12640-015-9544-x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sleep is indispensable for maintaining regular daily life activities and is of fundamental physiological importance for cognitive performance. Sleep deprivation (SD) may affect learning capacity and the ability to form new memories, particularly with regard to hippocampus-dependent tasks. Transcranial magnetic stimulation (TMS) is a non-invasive procedure of electromagnetic induction that generates electric currents, activating nearby nerve cells in the stimulated cortical area. Several studies have looked into the potential therapeutic use of TMS. The present study was designed to evaluate how TMS could improve learning and memory functions following SD in Octodon degus. Thirty juvenile (18 months old) females were divided into three groups (control, acute, and chronic TMS treatment-with and without SD). TMS-treated groups were placed in plastic cylindrical cages designed to keep them immobile, while receiving head magnetic stimulation. SD was achieved by gently handling the animals to keep them awake during the night. Behavioral tests included radial arm maze (RAM), Barnes maze (BM), and novel object recognition. When TMS treatment was applied over several days, there was significant improvement of cognitive performance after SD, with no side effects. A single TMS session reduced the number of errors for the RAM test and improved latency and reduced errors for the BM test, which both evaluate spatial memory. Moreover, chronic TMS treatment brings about a significant improvement in both spatial and working memories.

引用

页码：361 / 371

页数：11

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