Neuroanatomical dissociation of encoding processes related to priming and explicit memory

被引:53
作者
Schott, BH
Richardson-Klavehn, A
Henson, RNA
Becker, C
Heinze, HJ
Düzel, E
机构
[1] Univ London Goldsmiths Coll, Dept Psychol, London SE14 6NW, England
[2] Otto Von Guericke Univ, Ctr Adv Imaging, D-39120 Magdeburg, Germany
[3] Otto Von Guericke Univ, Dept Neurol 2, D-39120 Magdeburg, Germany
[4] MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England
基金
英国医学研究理事会;
关键词
priming; explicit memory; encoding; event-related fMRI; medial temporal lobe; extrastriate cortex; fusiform gyrus; prefrontal cortex;
D O I
10.1523/JNEUROSCI.2402-05.2006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Priming is a facilitation of cognitive processing with stimulus repetition that can occur without explicit memory. Whereas the functional neuroanatomy of perceptual priming at retrieval is established, encoding processes that initiate priming and explicit memory have not yet been anatomically separated, and we investigated them using event-related functional magnetic resonance imaging. Activations predicting later explicitmemoryoccurred in the bilateral medial temporal lobe (MTL) and left prefrontal cortex (PFC). Activity predicting later priming did not occur in these areas, but rather in the bilateral extrastriate cortex, left fusiform gyrus, and bilateral inferior PFC, areas linked with stimulus identification. Surprisingly, these regions showed response reductions. Our results demonstrate that priming and explicit memory have distinct functional neuroanatomies at encoding, with MTL activations being specific for explicit memory, and suggest that priming is initiated by sharpness of neural responding in stimulus identification areas, consistent with recent electrophysiological evidence regarding priming-related neural oscillations at encoding. We tentatively suggest that this sharpened responding at encoding may set the stage for increased neural processing efficiency at retrieval, with these different neural mechanisms both leading to observed priming-related hemodynamic decreases, and argue that neural measurements at encoding, and not just at retrieval, will be critical in resolving the debate about the neural mechanisms of learning that underlie priming.
引用
收藏
页码:792 / 800
页数:9
相关论文
共 52 条
[1]   Parietal cortex and attention [J].
Behrmann, M ;
Geng, JJ ;
Shomstein, S .
CURRENT OPINION IN NEUROBIOLOGY, 2004, 14 (02) :212-217
[2]  
Bowers J. S., 2003, Rethinking implicit memory
[3]   Making memories: Brain activity that predicts how well visual experience will be remembered [J].
Brewer, JB ;
Zhao, Z ;
Desmond, JE ;
Glover, GH ;
Gabrieli, JDE .
SCIENCE, 1998, 281 (5380) :1185-1187
[4]   Functional MRI evidence for a role of frontal and inferior temporal cortex in amodal components of priming [J].
Buckner, RL ;
Koutstaal, W ;
Schacter, DL ;
Rosen, BR .
BRAIN, 2000, 123 :620-640
[5]   Cognitive neuroscience of episodic memory encoding [J].
Buckner, RL ;
Logan, J ;
Donaldson, DI ;
Wheeler, ME .
ACTA PSYCHOLOGICA, 2000, 105 (2-3) :127-139
[6]   Neuroimaging of cognitive functions in human parietal cortex [J].
Culham, JC ;
Kanwisher, NG .
CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (02) :157-163
[8]   Early, partly anticipatory, neural oscillations during identification set the stage for priming [J].
Düzel, E ;
Richardson-Klavehn, A ;
Neufang, M ;
Schott, BH ;
Scholz, M ;
Heinze, HJ .
NEUROIMAGE, 2005, 25 (03) :690-700
[9]   Remembering episodes: a selective role for the hippocampus during retrieval [J].
Eldridge, LL ;
Knowlton, BT ;
Furmanski, CS ;
Bookheimer, SY ;
Engel, SA .
NATURE NEUROSCIENCE, 2000, 3 (11) :1149-1152
[10]   Dynamic predictions: Oscillations and synchrony in top-down processing [J].
Engel, AK ;
Fries, P ;
Singer, W .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (10) :704-716