MEF Promotes Stemness in the Pathogenesis of Gliomas

被引：38

作者：

Bazzoli, Elena ^{[1
,2
,3
,4
,7
]}

Pulvirenti, Teodoro ^{[5
]}

Oberstadt, Moritz C. ^{[1
,2
,6
]}

Perna, Fabiana ^{[7
]}

Wee, Boyoung ^{[1
,2
]}

Schultz, Nikolaus ^{[8
]}

Huse, Jason T. ^{[2
,9
]}

Fomchenko, Elena I. ^{[1
,2
]}

Voza, Francesca ^{[7
]}

Tabar, Viviane ^{[10
]}

Brennan, Cameron W. ^{[2
,10
]}

DeAngelis, Lisa M. ^{[2
,3
]}

Nimer, Stephen D. ^{[2
,7
]}

Holland, Eric C. ^{[1
,2
,10
]}

Squatrito, Massimo ^{[1
,2
]}

机构：

[1] Azienda Osped Univ lntegrata, Canc Biol & Genet Program, I-37134 Verona, Italy

[2] Azienda Osped Univ lntegrata, Brain Tumor Ctr, I-37134 Verona, Italy

[3] Azienda Osped Univ lntegrata, Dept Neurol, I-37134 Verona, Italy

[4] Azienda Osped Univ lntegrata, Dept Neurol Neuropsychol Morphol & Motor Sci, I-37134 Verona, Italy

[5] Ernst Moritz Arndt Univ Greifswald, Cell Biol Program, D-17487 Greifswald, Germany

[6] Ernst Moritz Arndt Univ Greifswald, Dept Pharmacol, D-17487 Greifswald, Germany

[7] Mem Sloan Kettering Canc Ctr, Mol Pharmacol & Chem Program, New York, NY 10021 USA

[8] Mem Sloan Kettering Canc Ctr, Computat Biol Program, New York, NY 10021 USA

[9] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[10] Mem Sloan Kettering Canc Ctr, Dept Neurosurg, New York, NY 10021 USA

来源：

CELL STEM CELL | 2012年 / 11卷 / 06期

关键词：

SELF-RENEWAL; CELLS; TUMORIGENICITY; EXPRESSION;

D O I：

10.1016/j.stem.2012.09.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

引用

页码：836 / 844

页数：9

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