Evidence for dietary regulation of microRNA expression in cancer cells

被引：84

作者：

Davis, Cindy D. ^{[1
]}

Ross, Sharon A. ^{[1
]}

机构：

[1] NCI, Nutr Sci Res Grp, Canc Prevent Div, Bethesda, MD 20892 USA

来源：

NUTRITION REVIEWS | 2008年 / 66卷 / 08期

关键词：

cancer; curcumin; folate; microRNA; retinoic acid;

D O I：

10.1111/j.1753-4887.2008.00080.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

MicroRNAs (miRNAs) are an abundant class of short noncoding RNAs that are widely expressed in mammalian cells and are important in post-translational gene regulation, including regulation of cell proliferation, apoptosis, and differentiation processes. miRNAs are involved in cancer initiation and progression and their expression patterns serve as phenotypic signatures of different cancers. Recent evidence suggests that dietary components as diverse as folate, retinoids, and curcumin exert cancer-protective effects through modulation of miRNA expression. miRNAs may be useful as biomarkers of cancer prevention or nutritional status, as well as serve as potential molecular targets that are influenced by dietary interventions. (C) 2008 International Life Sciences Institute.

引用

页码：477 / 482

页数：6

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