Electroconvulsive therapy induced gray matter increase is not necessarily correlated with clinical data in depressed patients

被引：43

作者：

Sartorius, Alexander ^{[1
,2
]}

Demirakca, Traute ^{[3
]}

Boehringer, Andreas ^{[2
]}

von Hohenberg, Christian Clemm ^{[1
,2
]}

Aksay, Suna Su ^{[2
]}

Bumb, Jan Malte ^{[4
]}

Kranaster, Laura ^{[2
]}

Nickl-Jockschat, Thomas ^{[5
,6
]}

Groezinger, Michael ^{[5
]}

Thomann, Philipp A. ^{[7
,8
]}

Wolf, Robert Christian ^{[7
]}

Zwanzger, Peter ^{[9
,10
,11
]}

Dannlowski, Udo ^{[10
]}

Redlich, Ronny ^{[10
]}

Zavorotnyy, Maxim ^{[12
,13
]}

Zoellner, Rebecca ^{[12
]}

Methfessel, Isabel ^{[14
]}

Besse, Matthias ^{[14
]}

Zilles, David ^{[14
]}

Ende, Gabriele ^{[3
]}

机构：

[1] Heidelberg Univ, Res Grp Translat Imaging, Dept Neuroimaging, Cent Inst Mental Hlth,Med Fac Mannheim, Mannheim, Germany

[2] Heidelberg Univ, Dept Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, J5, D-68159 Mannheim, Germany

[3] Heidelberg Univ, Dept Neuroimaging, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany

[4] Heidelberg Univ, Dept Addict Behav & Addict Med, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany

[5] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

[6] Univ Iowa, Dept Psychiat, Iowa Neurosci Inst, Carver Coll Med, Iowa City, IA 52242 USA

[7] Heidelberg Univ, Dept Gen Psychiat, Ctr Psychosocial Med, Heidelberg, Germany

[8] Uniklin RWTH, Ctr Mental Hlth, Odenwald Dist Healthcare Ctr, Aachen, Germany

[9] Kbo Inn Salzach Hosp, Gabersee 7, D-83512 Wasserburg, Germany

[10] Univ Munster, Dept Psychiat & Psychotherapy, Albert Schweitzer Campus 1, Munster, Germany

[11] Ludwig Maximilian Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany

[12] Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany

[13] Univ Marburg, MCMBB, Marburg, Germany

[14] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

来源：

BRAIN STIMULATION | 2019年 / 12卷 / 02期

关键词：

Depression; Electroconvulsive therapy; Gray matter; Hippocampus; Amygdala; ECT SEIZURE QUALITY; HIPPOCAMPAL VOLUME; SERUM BDNF; HABENULAR COMPLEX; BRAIN; DISORDERS; METAANALYSIS; CONCEPTUALIZATION; SCHIZOPHRENIA; NEUROTROPHINS;

D O I：

10.1016/j.brs.2018.11.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Electroconvulsive therapy (ECT) and depression have been associated with brain volume changes, especially in the hippocampus and the amygdala. Methods: In this retrospective study we collected data from individual pre-post ECT whole brain magnetic resonance imaging scans of depressed patients from six German university hospitals. Gray matter volume (GMV) changes were quantified via voxel-based morphometry in a total sample of 92 patients with major depressive episodes (MDE). Additionally, 43 healthy controls were scanned twice within a similar time interval. Results: Most prominently longitudinal GMV increases occurred in temporal lobe regions. Within specific region of interests we detected significant increases of GMV in the hippocampus and the amygdala. These results were more pronounced in the right hemisphere. Decreases in GMV were not observed. GMV changes did not correlate with psychopathology, age, gender or number of ECT sessions. We ruled out white matter reductions as a possible indirect cause of the detected GMV increase. Conclusion: The present findings support the notion of hippocampus and amygdala modulation following an acute ECT series in patients with MDE. These results corroborate the hypothesis that ECT enables primarily unspecific and regionally dependent neuroplasticity effects to the brain. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：335 / 343

页数：9

共 67 条

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