Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria

被引:256
作者
van Ingen, Jakko [2 ]
Boeree, Martin J. [1 ]
van Soolingen, Dick [1 ,2 ]
Mouton, Johan W. [2 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Resp Dis, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Clin Microbiol, NL-6500 HB Nijmegen, Netherlands
关键词
Mycobacteria; Nontuberculous mycobacteria; Drug susceptibility; Macrolides; Resistance; INTRINSIC MULTIDRUG-RESISTANCE; IN-VITRO SUSCEPTIBILITY; PROPORTION DILUTION METHOD; AVIUM COMPLEX DISEASE; 23S RIBOSOMAL-RNA; MACROLIDE RESISTANCE; ANTIBIOTIC-RESISTANCE; EFFLUX PUMP; MULTISITE REPRODUCIBILITY; CLINICAL-RELEVANCE;
D O I
10.1016/j.drup.2012.04.001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nontuberculous mycobacteria (NTM) are increasingly recognized as causative agents of opportunistic infections in humans. For most NTM infections the therapy of choice is drug treatment, but treatment regimens differ by species, in particular between slow (e.g. Mycobacterium avium complex, Mycobacterium kansasii) and rapid growers (e.g. Mycobacterium abscessus, Mycobacterium fortuitum). In general, drug treatment is long, costly, and often associated with drug-related toxicities; outcome of drug treatment is poor and is likely related to the high levels of natural antibiotic resistance in NTM. The role of drug susceptibility testing (DST) in the choice of agents for antimicrobial treatment of NTM disease, mainly that by slow growers, remains subject of debate. There are important discrepancies between drug susceptibility measured in vitro and the activity of the drug observed in vivo. In part, these discrepancies derive from laboratory technical issues. There is still no consensus on a standardized method. With the increasing clinical importance of NTM disease, DST of NTM is again in the spotlight. This review provides a comprehensive overview of the mechanisms of drug resistance in NTM, phenotypic methods for testing susceptibility in past and current use for DST of NTM, as well as molecular approaches to assess drug resistance. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:149 / 161
页数:13
相关论文
共 140 条
[1]   Acetylation and nitrosation of ciprofloxacin by environmental strains of mycobacteria [J].
Adjei, Michael D. ;
Heinze, Thomas M. ;
Deck, Joanna ;
Freeman, James P. ;
Williams, Anna J. ;
Sutherland, John B. .
CANADIAN JOURNAL OF MICROBIOLOGY, 2007, 53 (01) :144-147
[2]   Transformation of the antibacterial agent norfloxacin by environmental mycobacteria [J].
Adjei, Michael D. ;
Heinze, Thomas M. ;
Deck, Joanna ;
Freeman, James P. ;
Williams, Anna J. ;
Sutherland, John B. .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (09) :5790-5793
[3]  
AHN CH, 1987, AM REV RESPIR DIS, V135, P10
[4]  
Aínsa JA, 1998, J BACTERIOL, V180, P5836
[5]   Pharmacokinetics of Rifampin and Clarithromycin in Patients Treated for Mycobacterium ulcerans Infection [J].
Alffenaar, J. W. C. ;
Nienhuis, W. A. ;
de Velde, F. ;
Zuur, A. T. ;
Wessels, A. M. A. ;
Almeida, D. ;
Grosset, J. ;
Adjei, O. ;
Uges, D. R. A. ;
van der Werf, T. S. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (09) :3878-3883
[6]  
[Anonymous], 2006, 207761 ISO
[7]   Sixty-three cases of Mycobacterium marinum infection -: Clinical features, treatment, and antibiotic susceptibility of causative isolates [J].
Aubry, A ;
Chosidow, O ;
Caumes, E ;
Robert, J ;
Cambau, E .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (15) :1746-1752
[8]   Antibiotic susceptibility pattern of Mycobacterium marinum [J].
Aubry, A ;
Jarlier, V ;
Escolano, S ;
Truffot-Pernot, C ;
Cambau, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :3133-3136
[9]   COMBINED VERSUS SINGLE ANTITUBERCULOSIS DRUGS ON THE INVITRO SENSITIVITY PATTERNS OF NONTUBERCULOUS MYCOBACTERIA [J].
BANKS, J ;
JENKINS, PA .
THORAX, 1987, 42 (11) :838-842
[10]   Assessment of Clarithromycin Susceptibility in Strains Belonging to the Mycobacterium abscessus Group by erm(41) and rrl Sequencing [J].
Bastian, Sylvaine ;
Veziris, Nicolas ;
Roux, Anne-Laure ;
Brossier, Florence ;
Gaillard, Jean-Louis ;
Jarlier, Vincent ;
Cambau, Emmanuelle .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (02) :775-781