Role of Pigment Epithelium-Derived Factor in Stem/Progenitor Cell-Associated Neovascularization

被引：49

作者：

Liu, Jung-Tung ^{[3
]}

Chen, Yuh-Lien ^{[4
]}

Chen, Wen-Chi ^{[5
,6
,7
,8
,9
]}

Chen, Huey-Yi ^{[5
,6
,7
,8
,9
]}

Lin, Yi-Wen ^{[5
,6
]}

Wang, Shu-Huei ^{[4
]}

Man, Kee-Ming ^{[10
]}

Wan, Hui-Min ^{[1
,2
]}

Yin, Wei-Hsian ^{[11
]}

Liu, Po-Len ^{[1
,2
]}

Chen, Yung-Hsiang ^{[5
,6
,7
,8
,9
]}

机构：

[1] Kaohsiung Med Univ, Coll Med, Dept Fragrance & Cosmet Sci, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Coll Med, Dept Resp Therapy, Kaohsiung 807, Taiwan

[3] Chung Shan Med Univ & Hosp, Sch Med, Dept Neurosurg, Taichung 402, Taiwan

[4] Natl Taiwan Univ, Coll Med, Dept Anat & Cell Biol, Taipei 100, Taiwan

[5] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung 404, Taiwan

[6] China Med Univ, Coll Chinese Med, Grad Inst Acupuncture Sci, Taichung 404, Taiwan

[7] China Med Univ Hosp, Dept Urol, Taichung 404, Taiwan

[8] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung 404, Taiwan

[9] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[10] Tungs Taichung Metroharbor Hosp, Dept Anesthesiol, Taichung 433, Taiwan

[11] Natl Yang Ming Univ, Fac Med, Sch Med, Taipei 112, Taiwan

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

关键词：

ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL STEM-CELLS; OXYGEN SPECIES GENERATION; VASCULAR NICHE; NADPH OXIDASE; FACTOR PEDF; POSTNATAL VASCULOGENESIS; OXIDATIVE STRESS; PROSTATE-CANCER; GROWTH-FACTORS;

D O I：

10.1155/2012/871272

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells. It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities. PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties. More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization. Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells. PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease. Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases. Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization.

引用

页数：10

共 96 条

[1] Pigment Epithelium-Derived Factor Prevents Melanoma Growth via Angiogenesis Inhibition [J].

Abe, Riichiro ;

Fujita, Yasuyuki ;

Yamagishi, Sho-ichi ;

Shimizu, Hiroshi .

CURRENT PHARMACEUTICAL DESIGN, 2008, 14 (36) :3802-3809

[2] Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone [J].

Andreu-Agullo, Celia ;

Manuel Morante-Redolat, Jose ;

Delgado, Ana C. ;

Farinas, Isabel .

NATURE NEUROSCIENCE, 2009, 12 (12) :1514-U57

[3] Adenovirally transduced bone marrow stromal cells differentiate into pigment epithelial cells and induce rescue effects in RCS rats [J].

Arnhold, Stefan ;

Heiduschka, Peter ;

Klein, Helmut ;

Absenger, Yvonne ;

Basnaoglu, Serkan ;

Kreppel, Florian ;

Henke-Fahle, Sylvia ;

Kochanek, Stefan ;

Bartz-Schmidt, Karl-Ulrich ;

Addicks, Klaus ;

Schraermeyer, Ulrich .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (09) :4121-4129

[4] In vitro differentiation of retinal pigment epithelium from adult retinal stem cells [J].

Aruta, Claudia ;

Giordano, Francesca ;

De Marzo, Anna ;

Comitato, Antonella ;

Raposo, Graca ;

Nandrot, Emeline F. ;

Marigo, Valeria .

PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (01) :233-240

[5] Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[6] Concise Review: Circulating Endothelial Progenitor Cells for Vascular Medicine [J].

Asahara, Takayuki ;

Kawamoto, Atsuhiko ;

Masuda, Haruchika .

STEM CELLS, 2011, 29 (11) :1650-1655

[7] The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia [J].

Bauer, SM ;

Goldstein, LJ ;

Bauer, RJ ;

Chen, HY ;

Putt, M ;

Velazquez, OC .

JOURNAL OF VASCULAR SURGERY, 2006, 43 (01) :134-141

[8] Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration [J].

Bilak, MM ;

Corse, AM ;

Bilak, SR ;

Lehar, M ;

Tombran-Tink, J ;

Kuncl, RW .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (07) :719-728

[9] Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases [J].

Burt, Richard K. ;

Loh, Yvonne ;

Pearce, William ;

Beohar, Nirat ;

Barr, Walter G. ;

Craig, Robert ;

Wen, Yanting ;

Rapp, Jonathan A. ;

Kessler, John .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (08) :925-936

[10] Perspectives of Choroidal Neovascularization Therapy [J].

Caputo, M. ;

Zirpoli, H. ;

Di Benedetto, R. ;

De Nadai, K. ;

Tecce, M. F. .

CURRENT DRUG TARGETS, 2011, 12 (02) :234-242

← 1 2 3 4 5 6 7 8 9 10 →