Quartz tuning fork based sensor for detection of volatile organic compounds: towards breath analysis

被引:7
作者
Sampson, Abraham [1 ]
Panchal, Suresh [1 ]
Phadke, Apoorva [1 ]
Kashyap, A. [1 ]
Suman, Jilma [1 ]
Unnikrishnan, G. [1 ]
Datar, Suwarna [1 ]
机构
[1] Def Inst Adv Technol, Dept Appl Phys, Pune 411021, Maharashtra, India
关键词
breath analysis; quartz tuning fork; volatile organic compounds; linear discriminants analysis (LDA); EXHALED NITRIC-OXIDE; ELECTRONIC NOSE; LUNG-CANCER; BIOMARKERS; DISEASES; AMMONIA;
D O I
10.1088/2053-1591/aabbd2
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Several volatile organic compounds (VOCs) are present in the exhaled human breath whose concentration can vary depending on the physiological changes occurring within a human being. These changes in the concentration or the occurrence of a particular VOC can be used as signature of a particular disease in a person. In the present work, a sensor has been developed to detect VOCs such as 1,4-dimethoxy-2,3-butanediol (BD), and cyclohexanone (CH), acetone, methanol and ethanol. Except for BD and CH, the rest of the VOCs are present in a healthy person in ppm levels. CH and BD have been reported to be present in the exhaled human breath of breast cancer patients in ppm levels and can be used to distinguish between a healthy person and a person with breast cancer. The selectivity of the sensor towards these two compounds in the presence of other VOCs commonly present in human breath like acetone, ethanol and methanol has been studied. The sensor has been developed using modified Quartz Tuning Forks (QTFs) with the intent of developing an array of such sensors identifying different VOCs present in a healthy human's breath. Two differently modified QTFs have been used to detect 1 ppm of 1,4-dimethoxy-2,3-butanediol and 20 ppm of cyclohexanone. Linear Discriminants Analysis (LDA) has been used to classify seven different VOCs. For this purpose, features extracted from sensor responses -shift in resonant frequency, response time and recovery time of the sensors-have been used as features in the model. Differently modified array of QTFs along with the use of LDA can be a useful pathway towards development of a QTF based sensor array for human breath analysis.
引用
收藏
页数:10
相关论文
共 50 条
[41]   A novel, low-cost, portable PID sensor for the detection of volatile organic compounds [J].
Agbroko, Samuel O. ;
Covington, James .
SENSORS AND ACTUATORS B-CHEMICAL, 2018, 275 :10-15
[42]   Breath analysis using a spirometer and volatile organic compound sensor on driving simulator [J].
Itoh, Toshio ;
Sato, Toshihisa ;
Akamatsu, Takafumi ;
Shin, Woosuck .
JOURNAL OF BREATH RESEARCH, 2020, 14 (01)
[43]   Quartz Tuning Fork as in-situ sensor of bacterial biofilm [J].
Piasecki, Tomasz ;
Gula, Grzegorz ;
Waszczuk, Karol ;
Drulis-Kawa, Zuzanna ;
Gotszalk, Teodor .
28TH EUROPEAN CONFERENCE ON SOLID-STATE TRANSDUCERS (EUROSENSORS 2014), 2014, 87 :369-372
[44]   Transient parameters of a coated quartz-crystal microbalance sensor for the detection of volatile organic compounds (VOCs) [J].
Islam, AKMS ;
Ismail, Z ;
Ahmad, MN ;
Saad, B ;
Othman, AR ;
Shakaff, AYM ;
Daud, A ;
Ishak, Z .
SENSORS AND ACTUATORS B-CHEMICAL, 2005, 109 (02) :238-243
[45]   Quartz tuning fork-based biosensor for the direct detection of human cytomegalovirus [J].
Assaifan, Abdulaziz K. ;
Al-Gawati, Mahmoud A. ;
Alzahrani, Khalid E. ;
Alqahtani, Sultana F. ;
Aldakhil, Shatha M. ;
Alodhayb, Abdullah N. ;
Rahman, Shofiur ;
Albrithen, Hamad .
JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2023, 35 (05)
[46]   Blood and breath profiles of volatile organic compounds in patients with end-stage renal disease [J].
Mochalski, Pawel ;
King, Julian ;
Haas, Matthias ;
Unterkofler, Karl ;
Amann, Anton ;
Mayer, Gert .
BMC NEPHROLOGY, 2014, 15 :1-14
[47]   Comparison of sampling bags for the analysis of volatile organic compounds in breath [J].
Ghimenti, S. ;
Lomonaco, T. ;
Bellagambi, F. G. ;
Tabucchi, S. ;
Onor, M. ;
Trivella, M. G. ;
Ceccarini, A. ;
Fuoco, R. ;
Di Francesco, F. .
JOURNAL OF BREATH RESEARCH, 2015, 9 (04)
[48]   Diagnostic potential of breath analysis - focus on volatile organic compounds [J].
Miekisch, W ;
Schubert, JK ;
Noeldge-Schomburg, GFE .
CLINICA CHIMICA ACTA, 2004, 347 (1-2) :25-39
[49]   Nanostructured fiber optic sensors for detection of volatile organic compounds in breath [J].
Ruan, H. ;
Kang, Y. ;
Wang, Y-X. ;
Claus, R. O. .
OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS AND TREATMENT APPLICATIONS VI, 2006, 6083
[50]   Rapid detection of sepsis in rats through volatile organic compounds in breath [J].
Guaman, Ana V. ;
Carreras, Alba ;
Calvo, Daniel ;
Agudo, Idoya ;
Navajas, Daniel ;
Pardo, Antonio ;
Marco, Santiago ;
Farre, Ramon .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2012, 881-82 :76-82