The Role of the Keap1/Nrf2 Pathway in the Cellular Response to Methylmercury

被引：48

作者：

Kumagai, Yoshito ^{[1
,2
]}

Kanda, Hironori ^{[2
]}

Shinkai, Yasuhiro ^{[1
,2
]}

Toyama, Takashi ^{[2
]}

机构：

[1] Univ Tsukuba, Fac Med, Environm Biol Sect, Tsukuba, Ibaraki 3058575, Japan

[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Doctoral Program Biomed Sci, Tsukuba, Ibaraki 3058575, Japan

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2013年 / 2013卷

关键词：

GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; CYSTEINE LIGASE; TRANSCRIPTION FACTOR; SORBITOL DEHYDROGENASE; OXIDATIVE STRESS; MESSENGER-RNA; ENZYME GENES; NRF2; EXPRESSION; MICE;

D O I：

10.1155/2013/848279

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methylmercury (MeHg) is an environmental electrophile that covalently modifies cellular proteins with reactive thiols, resulting in the formation of protein adducts. While such protein modifications, referred to as S-mercuration, are thought to be associated with the enzyme dysfunction and cellular damage caused by MeHg exposure, the current consensus is that (1) there is a cellular response to MeHg through the activation of NF-E2-related factor 2 (Nrf2) coupled to S-mercuration of its negative regulator, Kelch-like ECH-associated protein 1 (Keap1), and (2) the Keap1/Nrf2 pathway protects against MeHg toxicity. In this review, we introduce our findings and discuss the observations of other workers concerning the S-mercuration of cellular proteins by MeHg and the importance of the Keap1/Nrf2 pathway in protection against MeHg toxicity in cultured cells and mice.

引用

页数：8

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