Chelate-soluble pectin fraction from papaya pulp interacts with galectin-3 and inhibits colon cancer cell proliferation

被引：41

作者：

Ramos do Prado, Samira Bernardino ^{[1
]}

Santos, Gustavo R. C. ^{[2
]}

Mourao, Paulo A. S. ^{[2
]}

Fabi, Joao Paulo ^{[1
,3
]}

机构：

[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP, Brazil

[2] Univ Fed Rio de Janeiro, Inst Med Biochem, Rio De Janeiro, Brazil

[3] CEPID FAPESP, Sao Paulo Res Fdn, Res Innovat & Disseminat Ctr, Food Res Ctr FoRC, Sao Paulo, SP, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019年 / 126卷

基金：

巴西圣保罗研究基金会;

关键词：

Papaya pectin; Galectin-3; Colon cancer; PHYSIOLOGICAL DEGRADATION; RHAMNOGALACTURONAN I; COLORECTAL-CANCER; FT-IR; POLYSACCHARIDES; SPECTROSCOPY; EXPRESSION; APOPTOSIS; PROSTATE; COMPLEX;

D O I：

10.1016/j.ijbiomac.2018.12.191

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer has an overexpression of galectin-3 that is related to cancer progression. A decreased risk of colon cancer can be related to consumption of dietary fibers, but the entire mechanism by which this protection occurs remains unclear. Pectin is a type of dietary fiber that possesses beta-galactosides and can bind and inhibit galectin-3-mediated effects. Papaya fruit has a massive cell wall disassembling during ripening that naturally changes its pectin structure. Our work shows that different points in the ripening time of papaya fruit exhibit pectins (chelate-soluble fractions; CSF) that can or cannot inhibit galectin-3. The fraction that inhibits galectin-3 (3CSF) also diminishes the proliferation of colon cancer cell lines, and it is derived from an intermediate point of papaya ripening. Therefore, we related this to a papaya pectin structure-dependent effect, and the papaya fruit seems to have a pectin structure that is promising in decreasing the risk of colon cancer development. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：170 / 178

页数：9

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