A Cationic High-Valent Cp*CoIII Complex for the Catalytic Generation of Nucleophilic Organometallic Species: Directed C-H Bond Activation

被引：383

作者：

Yoshino, Tatsuhiko ^{[1
]}

Ikemoto, Hideya ^{[1
]}

Matsunaga, Shigeki ^{[1
,3
]}

Kanai, Motomu ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Agcy, ERATO, Kanai Life Sci Catalysis Project, Bunkyo Ku, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy, ACT C, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 08期

关键词：

atom economy; CH activation; cobalt; homogeneous catalysis; nucleophilic addition; MANNICH-TYPE REACTIONS; CONJUGATE ADDITION; ASYMMETRIC 1,4-ADDITION; DIRECT ARYLATION; CARBON-HYDROGEN; N-ACYLPYRROLES; BENZOIC-ACIDS; FUNCTIONALIZATION; ALKYNES; ALDEHYDES;

D O I：

10.1002/anie.201209226

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Active without activation: In an inexpensive and atom-economical approach to C-H bond functionalization, a cationic CoIII complex (see scheme) was used to generate nucleophilic organometallic species in situ without additional activating reagents. Under these conditions, aryl C-H bonds underwent efficient addition to polar electrophiles, including α,β-unsaturated N-acyl pyrroles as β-substituted ester and amide surrogates. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2207 / 2211

页数：5

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