Hypoxia-inducible factor-1 as a therapeutic target in cancer

被引：104
作者：
Tang, Ceen-Ming [1 ,2 ,3 ]
Yu, Jun [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
[3] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2013年 / 28卷 / 03期
关键词：
angiogenesis; cyclooxygenase; drug reprofiling; hypoxia-inducible factor-1; intratumoral hypoxia; prostaglandins; sphingolipids; ENDOTHELIAL GROWTH-FACTOR; HIF-1 TRANSCRIPTIONAL ACTIVITY; PROSTAGLANDIN E-2; FACTOR; 1-ALPHA; TUMOR; FACTOR-1-ALPHA; EXPRESSION; ANGIOGENESIS; HIF-1-ALPHA; PROTEIN;
D O I：
10.1111/jgh.12038
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that immortalizes tumors by inducing key genes in cancer biology, including angiogenesis, glycolysis, invasion, and metastasis. Overexpression of HIF-1 alpha is thus associated with resistance to cancer chemotherapy and increased patient mortality in several cancer phenotypes. In the present review, we summarize the role of intratumoral hypoxia and bioactive lipids in enhancing HIF-1 activity, critically discussing the potential for HIF-1 alpha inhibitors in cancer chemotherapy. Considering preclinical studies, HIF-1 inhibitors appear to have antitumor effects and thus represent a novel therapeutic strategy.
引用
收藏
页码：401 / 405
页数：5
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