Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes

被引：24
|
作者：
Ye, Jixing [1 ]
Yang, Tian [2 ]
Guo, Haiying [2 ]
Tang, Yinhong [3 ]
Deng, Fang [2 ]
Li, Yuhong [2 ]
Xing, Yizhan [2 ]
Yang, Li [1 ]
Yang, Ke [2 ]
机构：
[1] Chongqing Univ, Bioengn Coll, Chongqing 400044, Peoples R China
[2] Third Mil Med Univ, Dept Cell Biol, Chongqing 400038, Peoples R China
[3] Med Univ Chongqing, Inst Basic Med, Dept Genet, Chongqing 400016, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2013年 / 10卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Wnt10b; Wnt/beta-catenin signaling; Hair follicle; Melanocyte; Differentiation; NEURAL CREST; BETA-CATENIN; TRANSCRIPTION FACTOR; STEM-CELLS; MELANIN SYNTHESIS; GENE-EXPRESSION; SKIN; ACTIVATION; GROWTH; FATE;
D O I：
10.7150/ijms.6170
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous research has revealed that Wnt10b activates canonical Wnt signaling, which is integral to melanocyte differentiation in hair follicles (HFs). However, the function of Wnt10b in HF melanocytes remains poorly understood. We determined using Dct-LacZ transgenic mice that Wnt10b is mainly expressed near and within melanocytes of the hair bulbs during the anagen stage of the hair cycle. We also found that Wnt10b promotes an increase in melanocyte maturation and pigmentation in the hair bulbs of the mouse HF. To further explore the potential functions of Wnt10b in mouse HF melanocytes, we infected iMC23 cells with Ad-Wnt10b to overexpress Wnt10b. We demonstrated that Wnt10b promotes the differentiation of melanocytes by activating canonical Wnt signaling in melanocytes.
引用
收藏
页码：691 / 698
页数：8
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