Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients

The aim of the present study was to investigate the relationships between interleukin 6 (IL-6) and insulin resistance, serum leptin, serum adiponectin, or serum lipids including triglycerides in 98 nonobese Japanese type 2 diabetic patients. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). Serum IL- 6 concentration was negatively correlated to high-density lipoprotein cholesterol (r = -0.295, P =.004), but was not associated with HOMA-IR (r = 0.016, P =.871), body mass index (BMI) (r = 0.090, P =.375), systolic (r = 0.169, P =.116) and diastolic (r = -0.061, P =.570) blood pressures, leptin (r = 0.062, P.544), and adiponectin (r = -0.020, P =.841) in these patients. In contrast, serum leptin level was positively correlated to HOMA-IR (r = 0.291, P =.004), BMI (r = 0.338, P <.001), and systolic blood pressure (r = 0.241, P =.025). Serum adiponectin level was negatively correlated to HOMA-IR (r = -0.288, P =.005), BMI (r = -0.308, P =.002), diastolic blood pressure (r = -0.269, P =.012), and triglycerides (r = - 0.338, P <.001), and positively correlated to high-density lipoprotein cholesterol (r = 0.300, P =.003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients. (c) 2006 Published by Elsevier Inc.