Sensitivity Alterable Biosensor Based on Gated Lateral BJT for CRP Detection

被引：6

作者：

Yuan, Heng ^{[1
]}

Kang, Byoung-Ho ^{[2
]}

Lee, Jae-Sung ^{[1
]}

Jeong, Hyun-Min ^{[1
]}

Yeom, Se-Hyuk ^{[2
]}

Kim, Kyu-Jin ^{[1
]}

Kwon, Dae-Hyuk ^{[3
]}

Kang, Shin-Won ^{[4
]}

机构：

[1] Kyungpook Natl Univ, Sch Elect Engn & Comp Sci, Taegu, South Korea

[2] Kyungpook Natl Univ, Ctr Funct Devices Fus Platform, Taegu, South Korea

[3] Kyungil Univ, Dept Elect Engn, Gyongsan, South Korea

[4] Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Taegu, South Korea

来源：

JOURNAL OF SEMICONDUCTOR TECHNOLOGY AND SCIENCE | 2013年 / 13卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Gated lateral BJT; MOSFET-BJT hybrid; biosensor; C-reactive protein; self-assembled monolayer (SAM); C-REACTIVE PROTEIN; 3-MERCAPTOPROPIONIC ACID; TRANSISTOR; MONOLAYERS;

D O I：

10.5573/JSTS.2013.13.1.001

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

In this paper, a biosensor based on a gated lateral bipolar junction transistor (BJT) is proposed. The gated lateral BJT can function as both a metaloxide-semiconductor field-effect transistor (MOSFET) and a BJT. By using the self-assembled monolayer (SAM) method, the C-reactive protein antibodies were immobilized on the floating gate of the device as the sensing membrane. Through the experiments, the characteristics of the biosensor were analyzed in this study. According to the results, it is indicated that the gated lateral BJT device can be successfully applied as a biosensor. Additionally, we found that the sensitivity of the gated lateral BJT can be varied by adjusting the emitter (source) bias.

引用

页码：1 / 7

页数：7

共 15 条

[1] A CMOS-Compatible, Low-Noise ISFET Based on High Efficiency Ion-Modulated Lateral-Bipolar Conduction [J].

Chang, Sheng-Ren ;

Chen, Hsin .

SENSORS, 2009, 9 (10) :8336-8348

[2] C-reactive protein and the risk of incident colorectal cancer [J].

Erlinger, TP ;

Platz, EA ;

Rifai, N ;

Helzlsouer, KJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (05) :585-590

[3]

Kwon H. C., 1999, IEEE ELECTR DEVICE L, V29, P1138

[4] Binding behavior of CRP and anti-CRP antibody analyzed with SPR and AFM measurement [J].

Lee, Soo-Keun ;

Kim, Hyun-Chul ;

Cho, Sang-Joon ;

Jeong, Sang Won ;

Jeon, Won Bae .

ULTRAMICROSCOPY, 2008, 108 (10) :1374-1378

[5] A comparative study of capacitive immunosensors based on self-assembled monolayers formed from thiourea, thioctic acid, and 3-mercaptopropionic acid [J].

Limbut, Warakorn ;

Kanatharana, Proespichaya ;

Mattiasson, Bo ;

Asawatreratanakul, Punnee ;

Thavarungkul, Panote .

BIOSENSORS & BIOELECTRONICS, 2006, 22 (02) :233-240

[6] CRP determination based on a novel magnetic biosensor [J].

Meyer, Martin H. F. ;

Hartmann, Markus ;

Krause, Hans-Joachim ;

Blankenstein, Gert ;

Mueller-Chorus, Birgit ;

Oster, Juergen ;

Miethe, Peter ;

Keusgen, Michael .

BIOSENSORS & BIOELECTRONICS, 2007, 22 (06) :973-979

[7] BIPOLAR FET HYBRID-MODE OPERATION OF QUARTER-MICROMETER SOI MOSFETS [J].

PARKE, SA ;

HU, CM ;

KO, PK .

IEEE ELECTRON DEVICE LETTERS, 1993, 14 (05) :234-236

[8] Mechanisms of disease - Atherosclerosis - An inflammatory disease [J].

Ross, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (02) :115-126

[9] Electrochemical responses of cytochrome c on a gold electrode modified with mixed monolayers of 3-mercaptopropionic acid and n-alkanethiol [J].

Sato, Y ;

Mizutani, F .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1997, 438 (1-2) :99-104

[10] Field-effect-transistor type C-reactive protein sensor using cysteine-tagged protein G [J].

Sohn, Y. -S. ;

Kim, Y. T. .

ELECTRONICS LETTERS, 2008, 44 (16) :955-956

← 1 2 →