Natural killer cell immunotherapy in glioblastoma

被引：16

作者：

Hosseinalizadeh, Hamed ^{[1
]}

Roudkenar, Mehryar Habibi ^{[2
,3
]}

Roushandeh, Amaneh Mohammadi ^{[2
,3
]}

Kuwahara, Yoshikazu ^{[4
]}

Tomita, Kazuo ^{[3
]}

Sato, Tomoaki ^{[3
]}

机构：

[1] Guilan Univ Med Sci, Fac Paramed, Dept Med Biotechnol, Rasht, Iran

[2] Guilan Univ Med Sci, Velayat Hosp, Sch Med, Burn & Regenerat Med Res Ctr, Rasht, Iran

[3] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Appl Pharmacol, Kagoshima, Japan

[4] Tohoku Med & Pharmaceut Univ, Fac Med, Div Radiat Biol & Med, Sendai, Miyagi, Japan

来源：

DISCOVER ONCOLOGY | 2022年 / 13卷 / 01期

关键词：

Glioblastoma; NK cells; Immunotherapy; POTENT ANTITUMOR-ACTIVITY; NK-CELLS; T-CELL; ADOPTIVE IMMUNOTHERAPY; TGF-BETA; TUMOR MICROENVIRONMENT; BISPECIFIC ANTIBODIES; CANCER-IMMUNOTHERAPY; ANTIGEN RECEPTOR; IMMUNE CELLS;

D O I：

10.1007/s12672-022-00567-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM have been used instead of conventional treatments. Among them, Natural killer (NK) cell-based immunotherapy has the potential to treat GBM due to its properties such as the absence of restriction by antigen-antibody reaction and deep penetration into the tumor microenvironment. Especially, genetically engineered NK cells, such as chimeric antigen receptor (CAR)-NK cells, dual antigen-targeting CAR NK cells, and adapter chimeric antigen receptor NK cells are considered to be an important tool for GBM immunotherapy. Therefore, this review describes the recent efforts of NK cell-based immunotherapy in GBM patients. We also describe key receptors expressing on NK cells such as killer cell immunoglobulin-like receptor, CD16, and natural killer group 2, member D (NKG2DL) receptor and discuss the function and importance of these molecules.

引用

页数：19

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