Post-processing strategies for improving local gene expression pattern analysis

被引:3
|
作者
Wang, Qiang [1 ]
Ye, Yunming [1 ]
Huang, Joshua Zhexue [2 ]
Feng, Shengzhong [2 ]
机构
[1] Harbin Inst Technol, Shenzhen Grad Sch, Dept Comp Sci, Shenzhen 518055, Peoples R China
[2] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
关键词
bioinformatics; microarray analysis; gene expression pattern analysis; soft subspace clustering; post-processing; GO; gene ontology; MICROARRAY DATA-ANALYSIS; CLUSTER VALIDATION; CLASSIFICATION; SELECTION; CANCER;
D O I
10.1504/IJDMB.2013.050976
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
This paper proposes a new analytical process highlighted by a soft subspace clustering method, a changing window technique, and a series of post-processing strategies to enhance the identification and characterisation of local gene expression patterns. The proposed method can be conducted in an interactive way, facilitating the exploration and analysis of local gene expression patterns in real applications. Experimental results have shown that the proposed method is effective in identification and characterization of functional gene groups in terms of both local expression similarities and biological coherence of genes in a cluster.
引用
收藏
页码:1 / 21
页数:21
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