Comparative Investigation of Protective Effects of Metyrosine and Metoprolol Against Ketamine Cardiotoxicity in Rats

被引：13

作者：

Ahiskalioglu, Ali ^{[1
]}

Ince, Ilker ^{[1
]}

Aksoy, Mehmet ^{[1
]}

Ahiskalioglu, Elif Oral ^{[2
]}

Comez, Mehmet ^{[2
]}

Dostbil, Aysenur ^{[1
]}

Celik, Mine ^{[1
]}

Alp, Hamit Hakan ^{[3
]}

Coskun, Resit ^{[4
]}

Taghizadehghalehjoughi, Ali ^{[5
]}

Suleyman, Bahadir ^{[6
]}

机构：

[1] Ataturk Univ, Fac Med, Dept Anaesthesiol & Reanimat, TR-25100 Erzurum, Turkey

[2] Reg Educ & Res Hosp, Dept Anaesthesiol & Reanimat, TR-25100 Erzurum, Turkey

[3] Yil Univ, Fac Med, Dept Biochem, TR-65000 Van, Turkey

[4] Bayburt State Hosp, Dept Cardiol, TR-69000 Bayburt, Turkey

[5] Ataturk Univ, Fac Med, Dept Pharmacol, TR-25100 Erzurum, Turkey

[6] Recep Tayyip Erdogan Univ, Fac Med, Dept Pharmacol, TR-53000 Rize, Turkey

来源：

CARDIOVASCULAR TOXICOLOGY | 2015年 / 15卷 / 04期

关键词：

Antioxidant; Cardiotoxicity; Ketamine; Metoprolol; Metyrosine; Oxidant; Rat; OXIDATIVE DNA-DAMAGE; ASSAY; CHROMATOGRAPHY; 8-OXOGUANINE; ANTIOXIDANT; CISPLATIN; BLOCKERS; TISSUE; BASES; ACID;

D O I：

10.1007/s12012-014-9301-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study investigated the effect of metyrosine against ketamine-induced cardiotoxicity in rats and compared the results with the effect of metoprolol. In this study, rats were divided into groups A, B and C. In group A, we investigated the effects of a single dose of metyrosine (150 mg/kg) and metoprolol (20 mg/kg) on single dose ketamine (60 mg/kg)-induced cardiotoxicity. In group B, we investigated the effect of metyrosine and metoprolol, which were given together with ketamine for 30 days. In group C, we investigated the effect of metyrosine and metoprolol given 15 days before ketamine and 30 days together with ketamine on ketamine cardiotoxicity. By the end of this process, we evaluated the effects of the levels of oxidant-antioxidant parameters such as MDA, MPO, 8-OHGua, tGSH, and SOD in addition to CK-MB and TP I on cardiotoxicity in rat heart tissue. The experimental results show that metyrosine prevented ketamine cardiotoxicity in groups A, B and C and metoprolol prevented it in only group C.

引用

页码：336 / 344

页数：9

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