HECT E3 Ligases: A Tale With Multiple Facets

被引：98
|
作者：
Weber, Janine [1 ]
Polo, Simona [1 ,2 ]
Maspero, Elena [1 ]
机构：
[1] Fdn Ist FIRC Oncol Mol, Milan, Italy
[2] Univ Milan, Dipartimento Oncol Ematooncol, Milan, Italy
来源：
FRONTIERS IN PHYSIOLOGY | 2019年 / 10卷
关键词：
ubiquitin; E3; ligase; cancer; inhibitor; HECT regulations; SMALL-MOLECULE INHIBITORS; UBIQUITIN-LIGASE; NEDD4; FAMILY; INDUCED SENESCENCE; WW DOMAINS; DEGRADATION; COMPLEX; CANCER; HUWE1; E6AP;
D O I：
10.3389/fphys.2019.00370
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Ubiquitination plays a pivotal role in several cellular processes and is critical for protein degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination cascade, responsible for substrate recognition. In order to achieve selectivity and specificity on their substrates, HECT E3 enzymes are tightly regulated and exert their function in a spatially and temporally controlled fashion in the cells. These characteristics made HECT E3s intriguing targets in drug discovery in the context of cancer biology.
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页数：8
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