Dobrava-Belgrade virus: Phylogeny, epidemiology, disease

被引：52

作者：

Papa, Anna ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Natl Reference Lab Arboviruses, Dept Microbiol A, Sch Med, GR-54006 Thessaloniki, Greece

来源：

ANTIVIRAL RESEARCH | 2012年 / 95卷 / 02期

关键词：

Dobrava-Belgrade virus; Hantavirus; Bunyavirus; Hemorrhagic fever with renal syndrome; Zoonosis; HANTAVIRUS NUCLEOCAPSID PROTEIN; HUMAN PATHOGENIC HANTAVIRUSES; SEVERE HEMORRHAGIC-FEVER; RENAL-SYNDROME; HANTAAN VIRUS; SEROLOGICAL DIAGNOSIS; APODEMUS-AGRARIUS; GENETIC DETECTION; DOBRAVA/BELGRADE VIRUS; ANTIGENIC PROPERTIES;

D O I：

10.1016/j.antiviral.2012.05.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dobrava-Belgrade virus (DOBV) is an Old World hantavirus that causes hemorrhagic fever with renal syndrome in humans. With a case fatality rate up to 12%. DOBV infection is the most life-threatening hantavirus disease in Europe. The virus was initially identified in the Balkans, but the discovery of new endemic foci have expanded its recognized geographic range. The recent description of novel genetic variants with different degrees of pathogenicity have complicated its taxonomic analysis. The original rodent host of DOBV is Apodemus flavicollis, however additional Apodemus species, such Apodemus agrarius and Apodemus ponticus, have been found to serve as hosts of the various DOBV genotypes. The complex evolution and genetic diversity of the virus are still under investigation. The present review aims to provide an update on the phylogeny of DOBV and the epidemiology of infection in rodents and humans; to describe the clinical characteristics of the disease; to present current knowledge about laboratory diagnosis, treatment and prevention; discuss the current state of the art in antiviral drug and vaccine development. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：104 / 117

页数：14

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