Hyperpolarization-activated current Ih in nucleus of solitary tract neurons:: Regional difference in serotonergic modulation

被引：9

作者：

Iwahori, Y ^{[1
]}

Ikegaya, Y ^{[1
]}

Matsuki, N ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Chem Pharmacol Lab, Tokyo 1130033, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2002年 / 88卷 / 04期

关键词：

nucleus of solitary tract; hyperpolarization-activated current; serotonin;

D O I：

10.1254/jjp.88.459

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The nucleus of solitary tract (NTS) contains diverse neural circuits responsible for basic vital functions. We examined the effect of serotonin (5-HT) on hyperpolarization-activated current (I-h) in neurons acutely isolated from caudal, medial and rostral parts of the NTS. Caudal and medial NTS neurons showed a large amplitude of I-h compared with rostral neurons. In these neurons, perfusion with 5-HT potentiated I-h amplitude in a concentration-dependent manner. The effect of 5-HT was blocked by NAN-190, a 5-HT1A receptor antagonist. Thus, 5-HT1A receptors may regulate I-h channel activity in caudal and medial NTS neurons.

引用

页码：459 / 462

页数：4

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