Synthesis and assembly behavior of nucleobase-functionalized block copolymers

被引：58
|
作者：
Spijker, Henri J. [1 ]
Dirks, A. J. [1 ]
Van Hest, Jan C. M. [1 ]
机构：
[1] Radboud Univ Nijmegen, Dept Organ Chem, Inst Mol & Mat, NL-6252 ED Nijmegen, Netherlands
来源：
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2006年 / 44卷 / 13期
关键词：
adenine; aggregation; atom transfer radical polymerization (ATRP); biomimetic; block copolymers; nucleobase interaction; thymine; LIVING RADICAL POLYMERIZATION; BUILDING-BLOCKS; POLYMERS; DNA; MONOMERS; NANOPARTICLES; URIDINE;
D O I：
10.1002/pola.21529
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The synthesis and assembly behavior of nucleobase-functionalized block copolymers were investigated. Four nucleons-functionalized block copolymers were synthesized in a controlled fashion with ATRP from a PEG-based macroinitiator of either thymine or adenine nucleobase-functional methacrylates. The two shorter block copolymers formed aggregates in water and CAC was determined with fluorescence spectroscopy. The separate block copolymers showed identical aggregation behavior, which indicated that the assembly was mainly governed by the hydrophobic-to-hydrophilic balance. The results suggested that besides the amphiphilic character, an additional parameter played a crucial role in the block copolymer assembly, namely, the interaction between the complementary thymine and adenine of the block copolymers by an improved shielding of the hydrophobic blocks.
引用
收藏
页码：4242 / 4250
页数：9
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