Room temperature N-heterocyclic carbene manganese catalyzed selective N-alkylation of anilines with alcohols

被引：135
|
作者：
Huang, Ming [1 ]
Li, Yukui [1 ]
Li, Yinwu [1 ]
Liu, Jiahao [1 ]
Shu, Siwei [2 ]
Liu, Yan [2 ]
Ke, Zhuofeng [1 ]
机构：
[1] Sun Yat Sen Univ, PCFM Lab, Sch Mat Sci & Engn, Guangzhou 510275, Guangdong, Peoples R China
[2] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 44期
关键词：
BORROWING HYDROGEN; SECONDARY ALCOHOLS; AROMATIC-AMINES; IRIDIUM COMPLEX; DEHYDROGENATION; AMINATION; EFFICIENT; METHANOL; REDUCTION; LIGAND;
D O I：
10.1039/c9cc02989c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation of anilines with alcohols by a bis-NHC manganese complex is presented. This system was applied to a large range of alcohols and anilines, including biologically relevant motifs and challenging methanol. Experimental and computational studies suggest an outer-sphere mechanism for this NHC-Mn system.
引用
收藏
页码：6213 / 6216
页数：4
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